Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2)
1_MNNFR 6_ ATILF 11_ WAAAA 16_ WAKSG 21_ KPSGE 26_ MDEVG 31_ VQKCK 36_ NALKL 41_ PVLEV 46_ LPGGG 51_ WDNLR 56_ NVDMG 61_ RVMEL 66_ TYSNC 71_ RTTED 76_ GQYII 81_ PDEIF 86_ TIPQK 91_ QSNLE 96_ MNSEI 101_ LESWA 106_ NYQSS 111_ TSYSI 116_ NTELS 121_ LFSKV 126_ NGKFS 131_ TEFQR 136_ MKTLQ 141_ VKDQA 146_ ITTRV 151_ QVRNL 156_ VYTVK 161_ INPTL 166_ ELSSG 171_ FRKEL 176_ LDISD 181_ RLENN 186_ QTRMA 191_ TYLAE 196_ LLVLN 201_ YGTHV 206_ TTSVD 211_ AGAAL 216_ IQEDH 221_ LRASF 226_ LQDSQ 231_ SSRSA 236_ VTASA 241_ GLAFQ 246_ NTVNF 251_ KFEEN 256_ YTSQN 261_ VLTKS 266_ YLSNR 271_ TNSRV 276_ QSIGG 281_ VPFYP 286_ GITLQ 291_ AWQQG 296_ ITNHL 301_ VAIDR 306_ SGLPL 311_ HFFIN 316_ PNMLP 321_ DLPGP 326_ LVKKV 331_ SKTVE 336_ TAVKR 341_ YYTFN 346_ TYPGC 351_ TDLNS 356_ PNFNF 361_ QANTD 366_ DGSCE 371_ GKMTN 376_ FSFGG 381_ VYQEC 386_ TQLSG 391_ NRDVL 396_ LCQKL 401_ EQKNP 406_ LTGDF 411_ SCPSG 416_ YSPVH 421_ LLSQI 426_ HEEGY 431_ NHLEC 436_ HRKCT 441_ LLVFC 446_ KTVCE 451_ DVFQV 456_ AKAEF 461_ RAFWC 466_ VASSQ 471_ VPENS 476_ GLLFG 481_ GLFSS 486_ KSINP 491_ MTNAQ 496_ SCPAG 501_ YFPLR 506_ LFENL 511_ KVCVS 516_ QDYEL 521_ GSRFA 526_ VPFGG 531_ FFSCT 536_ VGNPL 541_ VDPAI 546_ SRDLG 551_ APSLK 556_ KCPGG 561_ FSQHP 566_ ALISD 571_ GCQVS 576_ YCVKS 581_ GLFTG 586_ GSLPP 591_ ARLPP 596_ FTRPP 601_ LMSQA 606_ ATNTV 611_ IVTNS 616_ ENARS 621_ WIKDS 626_ QTHQW 631_ RLGEP 636_ IELRR 641_ AMNVI 646_ HGDGG 651_ GLSGG 656_ AAAGV 661_ TVGVT 666_ TILAV 671_ VITLA 676_ IYGTR 681_ KFKKK 686_ AYQAI 691_ EERQS 696_ LVPGT 701_ AATGD 706_ TTYQE 711_QGQSP
1: Pore-forming protein involved in both innate and adaptive immunity (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:31537793, PubMed:33224153). Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (By similarity). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:33224153). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity)
2: Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation (By similarity). Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells (By similarity). Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming (By similarity)