Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1)
1_MAVAP 6_ SFNMT 11_ NPQPA 16_ IEGGI 21_ SEVEI 26_ ISQQV 31_ DEETK 36_ SIAPV 41_ QLVNF 46_ AYRDL 51_ PLAAV 56_ DLSTA 61_ GSQLL 66_ SNLDE 71_ DYQRE 76_ GSNWL 81_ KPCCG 86_ KRAAV 91_ WQVFL 96_ LSASL 101_ NSFLV 106_ ACVIL 111_ VVILL 116_ TLELL 121_ IDIKL 126_ LQFSS 131_ AFQFA 136_ GVIHW 141_ ISLVI 146_ LSVFF 151_ SETVL 156_ RIVVL 161_ GIWDY 166_ IENKI 171_ EVFDG 176_ AVIIL 181_ SLAPM 186_ VASTV 191_ ANGPR 196_ SPWDA 201_ ISLII 206_ MLRIW 211_ RVKRV 216_ IDAYV 221_ LPVKL 226_ EMEMV 231_ IQQYE 236_ KAKVI 241_ QDEQL 246_ ERLTQ 251_ ICQEQ 256_ GFEIR 261_ QLRAH 266_ LAQQD 271_ LDLAA 276_ EREAA 281_ LQAPH 286_ VLSQP 291_ RSRFK 296_ VLEAG 301_ TWDEE 306_ TAAES 311_ VVEEL 316_ QPSQE 321_ ATMKD 326_ DMNSY 331_ ISQYY 336_ NGPSS 341_ DSGVP 346_ EPAVC 351_ MVTTA 356_ AIDIH 361_ QPNIS 366_ SDLFS 371_ LDMPL 376_ KLGGN 381_ GTSAT 386_ SESAS 391_ RSSVT 396_ RAQSD 401_ SSQTL 406_ GSSMD 411_ CSTAR 416_ EEPSS 421_ EPGPS 426_ PPPLP 431_ SQQQV 436_ EEATV 441_ QDLLS 446_ SLSED 451_ PCPSQ 456_ KALDP 461_ APLAR 466_ PSPAG 471_ SAQTS 476_ PELEH 481_ RVSLF 486_ NQKNQ 491_ EGFTV 496_ FQIRP 501_ VIHFQ 506_ PTVPM 511_ LEDKF 516_ RSLES 521_ KEQKL 526_HRVPE
1: Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529)