R-spondin-1 (Roof plate-specific spondin-1) (hRspo1)
1_MRLGL 6_ CVVAL 11_ VLSWT 16_ HLTIS 21_ SRGIK 26_ GKRQR 31_ RISAE 36_ GSQAC 41_ AKGCE 46_ LCSEV 51_ NGCLK 56_ CSPKL 61_ FILLE 66_ RNDIR 71_ QVGVC 76_ LPSCP 81_ PGYFD 86_ ARNPD 91_ MNKCI 96_ KCKIE 101_ HCEAC 106_ FSHNF 111_ CTKCK 116_ EGLYL 121_ HKGRC 126_ YPACP 131_ EGSSA 136_ ANGTM 141_ ECSSP 146_ AQCEM 151_ SEWSP 156_ WGPCS 161_ KKQQL 166_ CGFRR 171_ GSEER 176_ TRRVL 181_ HAPVG 186_ DHAAC 191_ SDTKE 196_ TRRCT 201_ VRRVP 206_ CPEGQ 211_ KRRKG 216_ GQGRR 221_ ENANR 226_ NLARK 231_ ESKEA 236_ GAGSR 241_ RRKGQ 246_ QQQQQ 251_ QGTVG 256_PLTSA
1: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805)