Tectonic-1
1_MRPRG 6_ LPPLL 11_ VVLLG 16_ CWASV 21_ SAQTD 26_ ATPAV 31_ TTEGL 36_ NSTEA 41_ ALATF 46_ GTFPS 51_ TRPPG 56_ TPRAP 61_ GPSSG 66_ PRPTP 71_ VTDVA 76_ VLCVC 81_ DLSPA 86_ QCDIN 91_ CCCDP 96_ DCSSV 101_ DFSVF 106_ SACSV 111_ PVVTG 116_ DSQFC 121_ SQKAV 126_ IYSLN 131_ FTANP 136_ PQRVF 141_ ELVDQ 146_ INPSI 151_ FCIHI 156_ TNYKP 161_ ALSFI 166_ NPEVP 171_ DENNF 176_ DTLMK 181_ TSDGF 186_ TLNAE 191_ SYVSF 196_ TTKLD 201_ IPTAA 206_ KYEYG 211_ VPLQT 216_ SDSFL 221_ RFPSS 226_ LTSSL 231_ CTDNN 236_ PAAFL 241_ VNQAV 246_ KCTRK 251_ INLEQ 256_ CEEIE 261_ ALSMA 266_ FYSSP 271_ EILRV 276_ PDSRK 281_ KVPIT 286_ VQSIV 291_ IQSLN 296_ KTLTR 301_ REDTD 306_ VLQPT 311_ LVNAG 316_ HFSLC 321_ VNVVL 326_ EVKYS 331_ LTYTD 336_ AGEVT 341_ KADLS 346_ FVLGT 351_ VSSVV 356_ VPLQQ 361_ KFEIH 366_ FLQEN 371_ TQPVP 376_ LSGNP 381_ GYVVG 386_ LPLAA 391_ GFQPH 396_ KGSGI 401_ IQTTN 406_ RYGQL 411_ TILHS 416_ TTEQD 421_ CLALE 426_ GVRTP 431_ VLFGY 436_ TMQSG 441_ CKLRL 446_ TGALP 451_ CQLVA 456_ QKVKS 461_ LLWGQ 466_ GFPDY 471_ VAPFG 476_ NSQAQ 481_ DMLDW 486_ VPIHF 491_ ITQSF 496_ NRKDS 501_ CQLPG 506_ ALVIE 511_ VKWTK 516_ YGSLL 521_ NPQAK 526_ IVNVT 531_ ANLIS 536_ SSFPE 541_ ANSGN 546_ ERTIL 551_ ISTAV 556_ TFVDV 561_ SAPAE 566_ AGFRA 571_ PPAIN 576_ ARLPF 581_NFFFP
1: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity)