E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
1_MASFP 6_ ETDFQ 11_ ICLLC 16_ KEMCG 21_ SPAPL 26_ SSNSS 31_ ASSSS 36_ SQTST 41_ SSGGG 46_ GGGPG 51_ AAARR 56_ LHVLP 61_ CLHAF 66_ CRPCL 71_ EAHRL 76_ PAAGG 81_ GAAGE 86_ PLKLR 91_ CPVCD 96_ QKVVL 101_ AEAAG 106_ MDALP 111_ SSAFL 116_ LSNLL 121_ DAVVA 126_ TADEP 131_ PPKNG 136_ RAGAP 141_ AGAGG 146_ HSNHR 151_ HHAHH 156_ AHPRA 161_ SASAP 166_ PLPQA 171_ PQPPA 176_ PSRSA 181_ PGGPA 186_ ASPSA 191_ LLLRR 196_ PHGCS 201_ SCDEG 206_ NAASS 211_ RCLDC 216_ QEHLC 221_ DNCVR 226_ AHQRV 231_ RLTKD 236_ HYIER 241_ GPPGP 246_ GAAAA 251_ AQQLG 256_ LGPPF 261_ PGPPF 266_ SILSV 271_ FPERL 276_ GFCQH 281_ HDDEV 286_ LHLYC 291_ DTCSV 296_ PICRE 301_ CTMGR 306_ HGGHS 311_ FIYLQ 316_ EALQD 321_ SRALT 326_ IQLLA 331_ DAQQG 336_ RQAIQ 341_ LSIEQ 346_ AQTVA 351_ EQVEM 356_ KAKVV 361_ QSEVK 366_ AVTAR 371_ HKKAL 376_ EEREC 381_ ELLWK 386_ VEKIR 391_ QVKAK 396_ SLYLQ 401_ VEKLR 406_ QNLNK 411_ LESTI 416_ SAVQQ 421_ VLEEG 426_ RALDI 431_ LLARD 436_ RMLAQ 441_ VQELK 446_ TVRSL 451_ LQPQE 456_ DDRVM 461_ FTPPD 466_ QALYL 471_ AIKSF 476_ GFVSS 481_ GAFAP 486_ LTKAT 491_ GDGLK 496_ RALQG 501_ KVASF 506_ TVIGY 511_ DHDGE 516_ PRLSG 521_ GDLMS 526_ AVVLG 531_ PDGNL 536_ FGAEV 541_ SDQQN 546_ GTYVV 551_ SYRPQ 556_ LEGEH 561_ LVSVT 566_ LCNQH 571_ IENSP 576_ FKVVV 581_ KSGRS 586_ YVGIG 591_ LPGLS 596_ FGSEG 601_ DSDGK 606_ LCRPW 611_ GVSVD 616_ KEGYI 621_ IVADR 626_ SNNRI 631_ QVFKP 636_ CGAFH 641_ HKFGT 646_ LGSRP 651_ GQFDR 656_ PAGVA 661_ CDASR 666_ RIVVA 671_ DKDNH 676_ RIQIF 681_ TFEGQ 686_ FLLKF 691_ GEKGT 696_ KNGQF 701_ NYPWD 706_ VAVNS 711_ EGKIL 716_ VSDTR 721_ NHRIQ 726_ LFGPD 731_ GVFLN 736_ KYGFE 741_ GALWK 746_ HFDSP 751_ RGVAF 756_ NHEGH 761_ LVVTD 766_ FNNHR 771_ LLVIH 776_ PDCQS 781_ ARFLG 786_ SEGTG 791_ NGQFL 796_ RPQGV 801_ AVDQE 806_ GRIIV 811_ ADSRN 816_ HRVQM 821_ FESNG 826_ SFLCK 831_ FGAQG 836_ SGFGQ 841_ MDRPS 846_ GIAIT 851_ PDGMI 856_ VVVDF 861_GNNRI
1: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233)