Transcriptional regulator QRICH1 (Glutamine-rich protein 1)
1_MNNSL 6_ ENTIS 11_ FEEYI 16_ RVKAR 21_ SVPQH 26_ RMKEF 31_ LDSLA 36_ SKGPE 41_ ALQEF 46_ QQTAT 51_ TTMVY 56_ QQGGN 61_ CIYTD 66_ STEVA 71_ GSLLE 76_ LACPV 81_ TTSVQ 86_ PQTQQ 91_ EQQIQ 96_ VQQPQ 101_ QVQVQ 106_ VQVQQ 111_ SPQQV 116_ SAQLS 121_ PQLTV 126_ HQPTE 131_ QPIQV 136_ QVQIQ 141_ GQAPQ 146_ SAAPS 151_ IQTPS 156_ LQSPS 161_ PSQLQ 166_ AAQIQ 171_ VQHVQ 176_ AAQQI 181_ QAAEI 186_ PEEHI 191_ PHQQI 196_ QAQLV 201_ AGQSL 206_ AGGQQ 211_ IQIQT 216_ VGALS 221_ PPPSQ 226_ QGSPR 231_ EGERR 236_ VGTAS 241_ VLQPV 246_ KKRKV 251_ DMPIT 256_ VSYAI 261_ SGQPV 266_ ATVLA 271_ IPQGQ 276_ QQSYV 281_ SLRPD 286_ LLTVD 291_ SAHLY 296_ SATGT 301_ ITSPT 306_ GETWT 311_ IPVYS 316_ AQPRG 321_ DPQQQ 326_ SITHI 331_ AIPQE 336_ AYNAV 341_ HVSGS 346_ PTALA 351_ AVKLE 356_ DDKEK 361_ MVGTT 366_ SVVKN 371_ SHEEV 376_ VQTLA 381_ NSLFP 386_ AQFMN 391_ GNIHI 396_ PVAVQ 401_ AVAGT 406_ YQNTA 411_ QTVHI 416_ WDPQQ 421_ QPQQQ 426_ TPQEQ 431_ TPPPQ 436_ QQQQQ 441_ LQVTC 446_ SAQTV 451_ QVAEV 456_ EPQSQ 461_ PQPSP 466_ ELLLP 471_ NSLKP 476_ EEGLE 481_ VWKNW 486_ AQTKN 491_ AELEK 496_ DAQNR 501_ LAPIG 506_ RRQLL 511_ RFQED 516_ LISSA 521_ VAELN 526_ YGLCL 531_ MTREA 536_ RNGEG 541_ EPYDP 546_ DVLYY 551_ IFLCI 556_ QKYLF 561_ ENGRV 566_ DDIFS 571_ DLYYV 576_ RFTEW 581_ LHEVL 586_ KDVQP 591_ RVTPL 596_ GYVLP 601_ SHVTE 606_ EMLWE 611_ CKQLG 616_ AHSPS 621_ TLLTT 626_ LMFFN 631_ TKYFL 636_ LKTVD 641_ QHMKL 646_ AFSKV 651_ LRQTK 656_ KNPSN 661_ PKDKS 666_ TSIRY 671_ LKALG 676_ IHQTG 681_ QKVTD 686_ DMYAE 691_ QTENP 696_ ENPLR 701_ CPIKL 706_ YDFYL 711_ FKCPQ 716_ SVKGR 721_ NDTFY 726_ LTPEP 731_ VVAPN 736_ SPIWY 741_ SVQPI 746_ SREQM 751_ GQMLT 756_ RILVI 761_ REIQE 766_ AIAVA 771_NASTM
1: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152)