WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]
1_MSIEI 6_ ESSDV 11_ IRLIM 16_ QYLKE 21_ NSLHR 26_ ALATL 31_ QEETT 36_ VSLNT 41_ VDSIE 46_ SFVAD 51_ INSGH 56_ WDTVL 61_ QAIQS 66_ LKLPD 71_ KTLID 76_ LYEQV 81_ VLELI 86_ ELREL 91_ GAARS 96_ LLRQT 101_ DPMIM 106_ LKQTQ 111_ PERYI 116_ HLENL 121_ LARSY 126_ FDPRE 131_ AYPDG 136_ SSKEK 141_ RRAAI 146_ AQALA 151_ GEVSV 156_ VPPSR 161_ LMALL 166_ GQALK 171_ WQQHQ 176_ GLLPP 181_ GMTID 186_ LFRGK 191_ AAVKD 196_ VEEEK 201_ FPTQL 206_ SRHIK 211_ FGQKS 216_ HVECA 221_ RFSPD 226_ GQYLV 231_ TGSVD 236_ GFIEV 241_ WNFTT 246_ GKIRK 251_ DLKYQ 256_ AQDNF 261_ MMMDD 266_ AVLCM 271_ CFSRD 276_ TEMLA 281_ TGAQD 286_ GKIKV 291_ WKIQS 296_ GQCLR 301_ RFERA 306_ HSKGV 311_ TCLSF 316_ SKDSS 321_ QILSA 326_ SFDQT 331_ IRIHG 336_ LKSGK 341_ TLKEF 346_ RGHSS 351_ FVNEA 356_ TFTQD 361_ GHYII 366_ SASSD 371_ GTVKI 376_ WNMKT 381_ TECSN 386_ TFKSL 391_ GSTAG 396_ TDITV 401_ NSVIL 406_ LPKNP 411_ EHFVV 416_ CNRSN 421_ TVVIM 426_ NMQGQ 431_ IVRSF 436_ SSGKR 441_ EGGDF 446_ VCCAL 451_ SPRGE 456_ WIYCV 461_ GEDFV 466_ LYCFS 471_ TVTGK 476_ LERTL 481_ TVHEK 486_ DVIGI 491_ AHHPH 496_ QNLIA 501_ TYSED 506_GLLKL
1: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (PubMed:24945353). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity)
2: (Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles