UV-stimulated scaffold protein A
1_MDQKL 6_ SKLVE 11_ ELTTS 16_ GEPRL 21_ NPEKM 26_ KELKK 31_ ICKSS 36_ EEQLS 41_ RAYRL 46_ LIAQL 51_ TQEHA 56_ EIRLS 61_ AFQIV 66_ EELFV 71_ RSHQF 76_ RMLVV 81_ SNFQE 86_ FLELT 91_ LGTDP 96_ AQPLP 101_ PPREA 106_ AQRLR 111_ QATTR 116_ AVEGW 121_ NEKFG 126_ EAYKK 131_ LALGY 136_ HFLRH 141_ NKKVD 146_ FQDTN 151_ ARSLA 156_ ERKRE 161_ EEKQK 166_ HLDKI 171_ YQERA 176_ SQAER 181_ EMQEM 186_ SGEIE 191_ SCLTE 196_ VESCF 201_ RLLVP 206_ FDFDP 211_ NPETE 216_ SLGMA 221_ SGMSD 226_ ALRSS 231_ CAGQV 236_ GPCRS 241_ GTPDP 246_ RDGEQ 251_ PCCSR 256_ DLPAS 261_ AGHPR 266_ AGGGA 271_ QPSQT 276_ ATGDP 281_ SDEDE 286_ DSDLE 291_ EFVRS 296_ HGLGS 301_ HKYTL 306_ DVELC 311_ SEGLK 316_ VQENE 321_ DNLAL 326_ IHAAR 331_ DTLKL 336_ IRNKF 341_ LPAVC 346_ SWIQR 351_ FTRVG 356_ THGGC 361_ LKRAI 366_ DLKAE 371_ LELVL 376_ RKYKE 381_ LDIEP 386_ EGGER 391_ RRTEA 396_ LGDAE 401_ EDEDD 406_ EDFVE 411_ VPEKE 416_ GYEPH 421_ IPDHL 426_ RPEYG 431_ LEAAP 436_ EKDTV 441_ VRCLR 446_ TRTRM 451_ DEEVS 456_ DPTSA 461_ AAQLR 466_ QLRDH 471_ LPPPS 476_ SASPS 481_ RALPE 486_ PQEAQ 491_ KLAAE 496_ RARAP 501_ VVPYG 506_ VDLHY 511_ WGQEL 516_ PTAGK 521_ IVKSD 526_ SQHRF 531_ WKPSE 536_ VEEEV 541_ VNADI 546_ SEMLR 551_ SRHIT 556_ FAGKF 561_ EPVQH 566_ WCRAP 571_ RPDGR 576_ LCERQ 581_ DRLKC 586_ PFHGK 591_ IVPRD 596_ DEGRP 601_ LDPED 606_ RAREQ 611_ RRQLQ 616_ KQERP 621_ EWQDP 626_ ELMRD 631_ VEAAT 636_ GQDLG 641_ SSRYS 646_ GKGRG 651_ KKRRY 656_ PSLTN 661_ LKAQA 666_ DTARA 671_ RIGRK 676_ VFAKA 681_ AVRRV 686_ VAAMN 691_ RMDQK 696_ KHEKF 701_SNQFN
1: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612, PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Acts as a key adapter that promotes recruitment of factors involved in TC-NER (PubMed:22466611, PubMed:22466612, PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II (PubMed:32142649, PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II (PubMed:38316879). Not involved in processing oxidative damage (PubMed:22466612)