Gene name: HFE

Uniprot entry:

Q30201

Protein names:

Hereditary hemochromatosis protein (HLA-H)

Protein sequence:

1_MGPRA 6_ RPALL 11_ LLMLL 16_ QTAVL 21_ QGRLL 26_ RSHSL 31_ HYLFM 36_ GASEQ 41_ DLGLS 46_ LFEAL 51_ GYVDD 56_ QLFVF 61_ YDHES 66_ RRVEP 71_ RTPWV 76_ SSRIS 81_ SQMWL 86_ QLSQS 91_ LKGWD 96_ HMFTV 101_ DFWTI 106_ MENHN 111_ HSKES 116_ HTLQV 121_ ILGCE 126_ MQEDN 131_ STEGY 136_ WKYGY 141_ DGQDH 146_ LEFCP 151_ DTLDW 156_ RAAEP 161_ RAWPT 166_ KLEWE 171_ RHKIR 176_ ARQNR 181_ AYLER 186_ DCPAQ 191_ LQQLL 196_ ELGRG 201_ VLDQQ 206_ VPPLV 211_ KVTHH 216_ VTSSV 221_ TTLRC 226_ RALNY 231_ YPQNI 236_ TMKWL 241_ KDKQP 246_ MDAKE 251_ FEPKD 256_ VLPNG 261_ DGTYQ 266_ GWITL 271_ AVPPG 276_ EEQRY 281_ TCQVE 286_ HPGLD 291_ QPLIV 296_ IWEPS 301_ PSGTL 306_ VIGVI 311_ SGIAV 316_ FVVIL 321_ FIGIL 326_ FIILR 331_ KRQGS 336_ RGAMG 341_HYVLA

Protein annotations

Protein functions:

1: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin