Beta-defensin 114 (Beta-defensin 14) (DEFB-14) (Defensin, beta 114)
1_MRIFY 6_ YLHFL 11_ CYVTF 16_ ILPAT 21_ CTLVN 26_ ADRCT 31_ KRYGR 36_ CKRDC 41_ LESEK 46_ QIDIC 51_ SLPRK 56_ ICCTE 61_KLYEE
1: Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality