tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog)
1_MVLWI 6_ LWRPF 11_ GFSGR 16_ FLKLE 21_ SHSIT 26_ ESKSL 31_ IPVAW 36_ TSLTQ 41_ MLLEA 46_ PGIFL 51_ LGQRK 56_ RFSTM 61_ PETET 66_ HERET 71_ ELFSP 76_ PSDVR 81_ GMTKL 86_ DRTAF 91_ KKTVN 96_ IPVLK 101_ VRKEI 106_ VSKLM 111_ RSLKR 116_ AALQR 121_ PGIRR 126_ VIEDP 131_ EDKES 136_ RLIML 141_ DPYKI 146_ FTHDS 151_ FEKAE 156_ LSVLE 161_ QLNVS 166_ PQISK 171_ YNLEL 176_ TYEHF 181_ KSEEI 186_ LRAVL 191_ PEGQD 196_ VTSGF 201_ SRIGH 206_ IAHLN 211_ LRDHQ 216_ LSFKH 221_ LIGQV 226_ MIDKN 231_ PGITS 236_ AVNKI 241_ NNIDN 246_ MYRNF 251_ QMEVL 256_ SGEQN 261_ MMTKV 266_ RENNY 271_ TYEFD 276_ FSKVY 281_ WNPRL 286_ STEHS 291_ RITEL 296_ LKPGD 301_ VLFDV 306_ FAGVG 311_ PFAIP 316_ VAKKN 321_ CTVFA 326_ NDLNP 331_ ESHKW 336_ LLYNC 341_ KLNKV 346_ DQKVK 351_ VFNLD 356_ GKDFL 361_ QGPVK 366_ EELMQ 371_ LLGLS 376_ KERKP 381_ SVHVV 386_ MNLPA 391_ KAIEF 396_ LSAFK 401_ WLLDG 406_ QPCSS 411_ EFLPI 416_ VHCYS 421_ FSKDA 426_ NPAED 431_ VRQRA 436_ GAVLG 441_ ISLEA 446_ CSSVH 451_ LVRNV 456_ APNKE 461_ MLCIT 466_ FQIPA 471_ SVLYK 476_ NQTRN 481_ PENHE 486_ DPPLK 491_ RQRTA 496_ EAFSD 501_EKTQI
1: Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding