Polycomb group RING finger protein 3 (RING finger protein 3A)
1_MLTRK 6_ IKLWD 11_ INAHI 16_ TCRLC 21_ SGYLI 26_ DATTV 31_ TECLH 36_ TFCRS 41_ CLVKY 46_ LEENN 51_ TCPTC 56_ RIVIH 61_ QSHPL 66_ QYIGH 71_ DRTMQ 76_ DIVYK 81_ LVPGL 86_ QEAEM 91_ RKQRE 96_ FYHKL 101_ GMEVP 106_ GDIKG 111_ ETCSA 116_ KQHLD 121_ SHRNG 126_ ETKAD 131_ DSSNK 136_ EAAEE 141_ KPEED 146_ NDYHR 151_ SDEQV 156_ SICLE 161_ CNSSK 166_ LRGLK 171_ RKWIR 176_ CSAQA 181_ TVLHL 186_ KKFIA 191_ KKLNL 196_ SSFNE 201_ LDILC 206_ NEEIL 211_ GKDHT 216_ LKFVV 221_ VTRWR 226_ FKKAP 231_ LLLHY 236_RPKMD
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)