Membrane-anchored junction protein
1_MSLKP 6_ FTYPF 11_ PETRF 16_ LHAGP 21_ NVYKF 26_ KIRYG 31_ KSIRG 36_ EEIEN 41_ KEVIT 46_ QELEV 51_ PVEKK 56_ AVGAV 61_ MRKRK 66_ HMDEP 71_ SSPSR 76_ PGLDR 81_ AKIGT 86_ SSQGP 91_ SKKKP 96_ PVETR 101_ RNRER 106_ KTQQG 111_ LQETL 116_ ASDIT 121_ DVQKQ 126_ DSEWG 131_ HSLPG 136_ RIVPP 141_ LQHNS 146_ PPPKE 151_ RAATG 156_ FFGFL 161_ SSLFP 166_ FRYFF 171_RKSSH
1: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane