Innate immunity activator protein
1_MLQMP 6_ KLNEI 11_ PPGRA 16_ GRREA 21_ RGEGR 26_ WPGQT 31_ GPEAA 36_ RLEWR 41_ AQGQA 46_ GGARA 51_ PWDSW 56_ GSSRL 61_ PTQPG 66_ PGWSR 71_ CPPSL 76_ LCALS 81_ FQKST 86_ MESKD 91_ EVSDT 96_ DSGII 101_ LQSGP 106_ DSPVS 111_ PMKEL 116_ THAVH 121_ KQQRA 126_ LEARL 131_ EACLE 136_ ELRRL 141_ CLREA 146_ ELTGT 151_ LPAEY 156_ PLKPG 161_ EKAPK 166_ VRRRI 171_ GAAYK 176_ LDDWA 181_ LHRED 186_ PLSSL 191_ ERQLA 196_ LQLQI 201_ TEAAR 206_ RLCLE 211_ ENLSR 216_ QARRQ 221_ RKHSM 226_ LQEEK 231_ KLQEL 236_ QRCLV 241_ ERRRN 246_ SEPPP 251_ AAALP 256_ LGREL 261_ SASDD 266_ SSLSD 271_ GLLLE 276_ EEESQ 281_ VPKPP 286_ PESPA 291_ PPSRP 296_ LPPQT 301_ LEGLQ 306_ PTGPE 311_ AGSPE 316_ RAPVQ 321_ NSPWK 326_ ETSLD 331_ HPYEK 336_ PRKSS 341_ EPWSE 346_ SSSPA 351_ TTPQD 356_ GPSAS 361_ SLWLL 366_ EPASY 371_ HVVPI 376_ RGVPG 381_ QWQGR 386_ TSAPA 391_ TPEIQ 396_ GRRGQ 401_ SQSLR 406_ VDSFR 411_ AGPEG 416_ RGRSA 421_ FPRRR 426_ PTHYT 431_ VTVPD 436_ SCFPA 441_ TKPPL 446_ PHAAC 451_ HSCSE 456_ DSGSD 461_ VSSIS 466_ HPTSP 471_ GSSSP 476_ DISFL 481_ QPLSP 486_ PKTHR 491_ HRGAW 496_ VPAGS 501_ RELVA 506_ HHPKL 511_ LLPPG 516_ YFPAG 521_ RYVVV 526_ AESPL 531_ PPGEW 536_ ELRRA 541_ APGPA 546_ YEEEG 551_ TPLRY 556_ QRLVP 561_ SRSRI 566_ VRTPS 571_ LKDSP 576_ AGRGL 581_ SKAAV 586_ SEELK 591_ WWHER 596_ ARLRS 601_ TRPHS 606_ LDRQG 611_ AFRVR 616_ SLPLG 621_ REGFG 626_ RALGP 631_ RAQVP 636_ TVCVL 641_ RRSPD 646_ GAPVQ 651_ VFVPE 656_KGEII
1: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262)