Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
1_MKAFG 6_ PPHEG 11_ PLQGL 16_ VASRI 21_ ETYGG 26_ RHRAS 31_ AQSTA 36_ GRLYP 41_ RGYPV 46_ LDPSR 51_ RRLQQ 56_ YVPFA 61_ RGSGQ 66_ ARGLS 71_ PMRLR 76_ DPEPE 81_ KRHGG 86_ HVGAG 91_ LLHSP 96_ KLKEL 101_ TKAHE 106_ LEVRL 111_ HTFSM 116_ FGMPR 121_ LPPED 126_ RRHWE 131_ IGEGG 136_ DSGLT 141_ IEKSW 146_ RELVP 151_ GHKEM 156_ SQELC 161_ HQQEA 166_ LWELL 171_ TTELI 176_ YVRKL 181_ KIMTD 186_ LLAAG 191_ LLNLQ 196_ RVGLL 201_ MEVSA 206_ ETLFG 211_ NVPSL 216_ IRTHR 221_ SFWDE 226_ VLGPT 231_ LEETR 236_ ASGQP 241_ LDPIG 246_ LQSGF 251_ LTFGQ 256_ RFHPY 261_ VQYCL 266_ RVKQT 271_ MAYAR 276_ EQQET 281_ NPLFH 286_ AFVQW 291_ CEKHK 296_ RSGRQ 301_ MLCDL 306_ LIKPH 311_ QRITK 316_ YPLLL 321_ HAVLK 326_ RSPEA 331_ RAQEA 336_ LNAMI 341_ EAVES 346_ FLRHI 351_ NGQVR 356_ QGEEQ 361_ ESLAA 366_ AAQRI 371_ GPYEV 376_ LEPPS 381_ DEVEK 386_ NLRPF 391_ STLDL 396_ TSPML 401_ GVASE 406_ HTRQL 411_ LLEGP 416_ VRVKE 421_ GREGK 426_ LDVYL 431_ FLFSD 436_ VLLVT 441_ KPQRK 446_ ADKAK 451_ VIRPP 456_ LMLEK 461_ LVCQP 466_ LRDPN 471_ SFLLI 476_ HLTEF 481_ QCVSS 486_ ALLVH 491_ CPSPT 496_ DRAQW 501_ LEKTQ 506_ QAQAA 511_ LQKLK 516_ AEEYV 521_ QQKRE 526_ LLTLY 531_ RDQDR 536_ ESPST 541_ RPSTP 546_ SLEGS 551_ QSSAE 556_ GRTPE 561_ FSTII 566_ PHLVV 571_ TEDTD 576_ EDAPL 581_ VPDDT 586_ SDSGY 591_ GTLIP 596_ GTPTG 601_ SRSPL 606_ SRLRQ 611_ RALRR 616_ DPRLT 621_ FSTLE 626_ LRDIP 631_ LRPHP 636_ PDPQA 641_ PQRRS 646_ APELP 651_ EGILK 656_ GGSLP 661_ QEDPP 666_ TWSEE 671_ EDGAS 676_ ERGNV 681_ VVETL 686_ HRARL 691_ RGQLP 696_ SSPTH 701_ ADSAG 706_ ESPWE 711_ SSGEE 716_ EEEGP 721_ LFLKA 726_ GHTSL 731_ RPMRA 736_ EDMLR 741_ EIREE 746_ LASQR 751_ IEGAE 756_ EPRDS 761_ RPRKL 766_ TRAQL 771_ QRMRG 776_ PHIIQ 781_LDTPL
1: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis