Protein Aster-B (GRAM domain-containing protein 1B)
1_MKGFK 6_ LSCTA 11_ SNSNR 16_ STPAC 21_ SPILR 26_ KRSRS 31_ PTPQN 36_ QDGDT 41_ MVEKG 46_ SDHSS 51_ DKSPS 56_ TPEQG 61_ VQRSC 66_ SSQSG 71_ RSGGK 76_ NSKKS 81_ QSWYN 86_ VLSPT 91_ YKQRN 96_ EDFRK 101_ LFKQL 106_ PDTER 111_ LIVDY 116_ SCALQ 121_ RDILL 126_ QGRLY 131_ LSENW 136_ ICFYS 141_ NIFRW 146_ ETLLT 151_ VRLKD 156_ ICSMT 161_ KEKTA 166_ RLIPN 171_ AIQVC 176_ TDSEK 181_ HFFTS 186_ FGARD 191_ RTYMM 196_ MFRLW 201_ QNALL 206_ EKPLC 211_ PKELW 216_ HFVHQ 221_ CYGNE 226_ LGLTS 231_ DDEDY 236_ VPPDD 241_ DFNTM 246_ GYCEE 251_ IPVEE 256_ NEVND 261_ SSSKS 266_ SIETK 271_ PDASP 276_ QLPKK 281_ SITNS 286_ TLTST 291_ GSSEA 296_ PVSFD 301_ GLPLE 306_ EEALE 311_ GDGSL 316_ EKELA 321_ IDNIM 326_ GEKIE 331_ MIAPV 336_ NSPSL 341_ DFNDN 346_ EDIPT 351_ ELSDS 356_ SDTHD 361_ EGEVQ 366_ AFYED 371_ LSGRQ 376_ YVNEV 381_ FNFSV 386_ DKLYD 391_ LLFTN 396_ SPFQR 401_ DFMEQ 406_ RRFSD 411_ IIFHP 416_ WKKEE 421_ NGNQS 426_ RVILY 431_ TITLT 436_ NPLAP 441_ KTATV 446_ RETQT 451_ MYKAS 456_ QESEC 461_ YVIDA 466_ EVLTH 471_ DVPYH 476_ DYFYT 481_ INRYT 486_ LTRVA 491_ RNKSR 496_ LRVST 501_ ELRYR 506_ KQPWG 511_ LVKTF 516_ IEKNF 521_ WSGLE 526_ DYFRH 531_ LESEL 536_ AKTES 541_ TYLAE 546_ MHRQS 551_ PKEKA 556_ SKTTT 561_ VRRRK 566_ RPHAH 571_ LRVPH 576_ LEEVM 581_ SPVTT 586_ PTDED 591_ VGHRI 596_ KHVAG 601_ STQTR 606_ HIPED 611_ TPNGF 616_ HLQSV 621_ SKLLL 626_ VISCV 631_ ICFSL 636_ VLLVI 641_ LNMML 646_ FYKLW 651_ MLEYT 656_ TQTLT 661_ AWQGL 666_ RLQER 671_ LPQSQ 676_ TEWAQ 681_ LLESQ 686_ QKYHD 691_ TELQK 696_ WREII 701_ KSSVM 706_ LLDQM 711_ KDSLI 716_ NLQNG 721_ IRSRD 726_ YTSES 731_EEKRN
1: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity)