Inactive Rho GTPase-activating protein 11B (Rho-type GTPase-activating protein 11B)
1_MWDQR 6_ LVKLA 11_ LLQHL 16_ RAFYG 21_ IKVKG 26_ VRGQC 31_ DRRRH 36_ ETAAT 41_ EIGGK 46_ IFGVP 51_ FNALP 56_ HSAVP 61_ EYGHI 66_ PSFLV 71_ DACTS 76_ LEEHI 81_ HTEGL 86_ FRKSG 91_ SVIRL 96_ KALKN 101_ KVDHG 106_ EGCLS 111_ SAPPC 116_ DIAGL 121_ LKQFF 126_ RELPE 131_ PILPA 136_ DLHEA 141_ LLKAQ 146_ QLGTE 151_ EKNKA 156_ ILLLS 161_ CLLAD 166_ HTVHV 171_ LRYFF 176_ NFLRN 181_ VSLRS 186_ SENKM 191_ DSSNL 196_ AVIFA 201_ PNLLQ 206_ TSEGH 211_ EKMSS 216_ NAEKK 221_ GVYQT 226_ LSWKR 231_ YQPCW 236_ VLMVS 241_ VLLHH 246_ WKALK 251_ KVNMK 256_ LLVNI 261_RERED
1: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627, PubMed:33938018). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544)