Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE)
1_MSLQA 6_ SEGCP 11_ GLGTN 16_ VFVPQ 21_ SPQTD 26_ EEGSR 31_ SGRSF 36_ SEFED 41_ TQDLD 46_ TPGLP 51_ PFCPM 56_ APWGS 61_ EEGLS 66_ PCHLL 71_ TVRVI 76_ RMKNV 81_ RQADM 86_ LSQTD 91_ CFVSL 96_ WLPTA 101_ SQKKL 106_ RTRTI 111_ SNCPN 116_ PEWNE 121_ SFNFQ 126_ IQSRV 131_ KNVLE 136_ LSVCD 141_ EDTVT 146_ PDDHL 151_ LTVLY 156_ DLTKL 161_ CFRKK 166_ THVKF 171_ PLNPQ 176_ GMEEL 181_ EVEFL 186_ LEESP 191_ SPPET 196_ LVTNG 201_ VLVSR 206_ QVSCL 211_ EVHAQ 216_ SRRRR 221_ KREKM 226_ KDLLV 231_ MVNES 236_ FENTQ 241_ RVRPC 246_ LEPCC 251_ PTSAC 256_ FQTAA 261_ CFHYP 266_ KYFQS 271_ QVHVE 276_ VPKSH 281_ WSCGL 286_ CCRSR 291_ KKGPI 296_ SQPLD 301_ CLSDG 306_ QVMTL 311_ PVGES 316_ YELHM 321_ KSTPC 326_ PETLD 331_ VRLGF 336_ SLCPA 341_ ELEFL 346_ QKRKV 351_ VVAKA 356_ LKQVL 361_ QLEED 366_ LQEDE 371_ VPLIA 376_ IMATG 381_ GGTRS 386_ MTSMY 391_ GHLLG 396_ LQKLN 401_ LLDCA 406_ SYITG 411_ LSGAT 416_ WTMAT 421_ LYRDP 426_ DWSSK 431_ NLEPA 436_ IFEAR 441_ RHVVK 446_ DKLPS 451_ LFPDQ 456_ LRKFQ 461_ EELRQ 466_ RSQEG 471_ YRVTF 476_ TDFWG 481_ LLIET 486_ CLGDE 491_ RNECK 496_ LSDQR 501_ AALSC 506_ GQNPL 511_ PIYLT 516_ INVKD 521_ DVSNQ 526_ DFREW 531_ FEFSP 536_ YEVGL 541_ QKYGA 546_ FIPSE 551_ LFGSE 556_ FFMGR 561_ LVKRI 566_ PESRI 571_ CYMLG 576_ LWSSI 581_ FSLNL 586_ LDAWN 591_ LSHTS 596_ EEFFH 601_ RWTRE 606_ KVQDI 611_ EDEPI 616_ LPEIP 621_ KCDAN 626_ ILETT 631_ VVIPG 636_ SWLSN 641_ SFREI 646_ LTHRS 651_ FVSEF 656_ HNFLS 661_ GLQLH 666_ TNYLQ 671_ NGQFS 676_ RWKDT 681_ VLDGF 686_ PNQLT 691_ ESANH 696_ LCLLD 701_ TAFFV 706_ NSSYP 711_ PLLRP 716_ ERKAD 721_ LIIHL 726_ NYCAG 731_ SQTKP 736_ LKQTC 741_ EYCTV 746_ QNIPF 751_ PKYEL 756_ PDENE 761_ NLKEC 766_ YLMEN 771_ PQEPD 776_ APIVT 781_ FFPLI 786_ NDTFR 791_ KYKAP 796_ GVERS 801_ PEELE 806_ QGQVD 811_ IYGPK 816_ TPYAT 821_ KELTY 826_ TEATF 831_ DKLVK 836_ LSEYN 841_ ILNNK 846_ DTLLQ 851_ ALRLA 856_ VEKKK 861_RLKGQ
1: Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity)