Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9)
1_MVPSR 6_ EALLG 11_ PGTTA 16_ IRCPK 21_ KLQNQ 26_ NYKGH 31_ GLSKG 36_ KEREQ 41_ RASIR 46_ FKTTL 51_ MNTLM 56_ DVLRH 61_ RPGWV 66_ EVKDE 71_ GEWDF 76_ YWCDV 81_ SWLRE 86_ NFDHT 91_ YMDEH 96_ VRISH 101_ FRNHY 106_ ELTRK 111_ NYMVK 116_ NLKRF 121_ RKQLE 126_ REAGK 131_ LEAAK 136_ CDFFP 141_ KTFEM 146_ PCEYH 151_ LFVEE 156_ FRKNP 161_ GITWI 166_ MKPVA 171_ RSQGK 176_ GIFLF 181_ RRLKD 186_ IVDWR 191_ KDTRS 196_ SDDQK 201_ DDIPV 206_ ENYVA 211_ QRYIE 216_ NPYLI 221_ GGRKF 226_ DLRVY 231_ VLVMS 236_ VFAEC 241_ LLWSG 246_ HRRQD 251_ VHLTN 256_ VAVQK 261_ TSPDY 266_ HPKKG 271_ CKWTL 276_ QRFRQ 281_ YLASK 286_ HGPEA 291_ VETLF 296_ RDIDN 301_ IFVKS 306_ LQSVQ 311_ KVIIS 316_ DKHCF 321_ ELYGY 326_ DILID 331_ QDLKP 336_ WLLEV 341_ NASPS 346_ LTASS 351_ QEDYE 356_ LKTCL 361_ LEDTL 366_ HVVDM 371_ EARLT 376_ GREKR 381_ VGGFD 386_ LMWND 391_ GPVSR 396_ EEGAP 401_ DLSGM 406_ GNFVT 411_ NTHLG 416_ CVNDR 421_ KKQLR 426_ QLFCS 431_LQVQK
1: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern