2-acylglycerol O-acyltransferase 2 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (hMGAT2) (Diacylglycerol O-acyltransferase candidate 5) (hDC5) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 2)
1_MVEFA 6_ PLFMP 11_ WERRL 16_ QTLAV 21_ LQFVF 26_ SFLAL 31_ AEICT 36_ VGFIA 41_ LLFTR 46_ FWLLT 51_ VLYAA 56_ WWYLD 61_ RDKPR 66_ QGGRH 71_ IQAIR 76_ CWTIW 81_ KYMKD 86_ YFPIS 91_ LVKTA 96_ ELDPS 101_ RNYIA 106_ GFHPH 111_ GVLAV 116_ GAFAN 121_ LCTES 126_ TGFSS 131_ IFPGI 136_ RPHLM 141_ MLTLW 146_ FRAPF 151_ FRDYI 156_ MSAGL 161_ VTSEK 166_ ESAAH 171_ ILNRK 176_ GGGNL 181_ LGIIV 186_ GGAQE 191_ ALDAR 196_ PGSFT 201_ LLLRN 206_ RKGFV 211_ RLALT 216_ HGAPL 221_ VPIFS 226_ FGEND 231_ LFDQI 236_ PNSSG 241_ SWLRY 246_ IQNRL 251_ QKIMG 256_ ISLPL 261_ FHGRG 266_ VFQYS 271_ FGLIP 276_ YRRPI 281_ TTVVG 286_ KPIEV 291_ QKTLH 296_ PSEEE 301_ VNQLH 306_ QRYIK 311_ ELCNL 316_ FEAHK 321_ LKFNI 326_PADQH
1: Involved in glycerolipid synthesis and lipid metabolism (PubMed:12621063, PubMed:18768481, PubMed:27184406, PubMed:28420705). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:27184406). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (By similarity). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 at sn-2 (PubMed:12621063). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol or 1-O-alkyl-2-acylglycerol) and subsequently, with lower efficiency, may add another acyl chain producing monoalkyl-diacylglycerol (MADAG, 1-O-alkyl-2,3-diacylglycerol) (PubMed:28420705). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:18768481)