Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2)
1_MSLLD 6_ GLASS 11_ PRAPL 16_ QSSKA 21_ RMKKL 26_ PKKSQ 31_ NEKYR 36_ LKYLR 41_ LRKAA 46_ KATVF 51_ ENAAI 56_ CDEIA 61_ RLEEK 66_ FLKAK 71_ EERRY 76_ LLKKL 81_ LQLQA 86_ LTEGE 91_ VQAAA 96_ PSHSS 101_ SLPLT 106_ YGVAS 111_ SVGTI 116_ QGAGP 121_ ISGPS 126_ TGAEE 131_ PFGKK 136_ TKKEK 141_ KEKGK 146_ ENNKL 151_ EVLKK 156_ TCKKK 161_ KMAGG 166_ ARKLV 171_ QPIAL 176_ DPSGR 181_ PVFPI 186_ GLGGL 191_ TVYSL 196_ GEIIT 201_ DRPGF 206_ HDESA 211_ IYPVG 216_ YCSTR 221_ IYASM 226_ KCPDQ 231_ KCLYT 236_ CQIKD 241_ GGVQP 246_ QFEIV 251_ PEDDP 256_ QNAIV 261_ SSSAD 266_ ACHAE 271_ LLRTI 276_ STTMG 281_ KLMPN 286_ LLPAG 291_ ADFFG 296_ FSHPA 301_ IHNLI 306_ QSCPG 311_ ARKCI 316_ NYQWV 321_ KFDVC 326_ KPGDG 331_ QLPEG 336_ LPEND 341_ AAMSF 346_ EAFQR 351_ QIFDE 356_ DQNDP 361_ LLPGS 366_ LDLPE 371_ LQPAA 376_ FVSSY 381_ QPMYL 386_ THEPL 391_ VDTHL 396_ QHLKS 401_ PSQGS 406_PIQSS
1: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability