Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)
1_MAVPG 6_ SFPLL 11_ VEGSW 16_ GPDPP 21_ KNLNT 26_ KLQMY 31_ FQSPK 36_ RSGGG 41_ ECEVR 46_ QDPRS 51_ PSRFL 56_ VFFYP 61_ EDVRQ 66_ KVLER 71_ KNHEL 76_ VWQGK 81_ GTFKL 86_ TVQLP 91_ ATPDE 96_ IDHVF 101_ EEELL 106_ TKESK 111_ TKEDV 116_ KEPDV 121_ SEELD 126_ TKLPL 131_ DGGLD 136_ KMEDI 141_ PEECE 146_ NISSL 151_ VAFEN 156_ LKANV 161_ TDIML 166_ ILLVE 171_ NISGL 176_ SNDDF 181_ QVEII 186_ RDFDV 191_ AVVTF 196_ QKHID 201_ TIRFV 206_ DDCTK 211_ HHSIK 216_ QLQLS 221_ PRLLE 226_ VTNTI 231_ RVENL 236_ PPGAD 241_ DYSLK 246_ LFFEN 251_ PYNGG 256_ GRVAN 261_ VEYFP 266_ EESSA 271_ LIEFF 276_ DRKVL 281_ DTIMA 286_ TKLDF 291_ NKMPL 296_ SVFPY 301_ YASLG 306_ TALYG 311_ KEKPL 316_ IKLPA 321_ PFEES 326_ LDLPL 331_ WKFLQ 336_ KKNHL 341_ IEEIN 346_ DEMRR 351_ CHCEL 356_ TWSQL 361_ SGKVT 366_ IRPAA 371_ TLVNE 376_ GRPRI 381_ KTWQA 386_ DTSTT 391_ LSSIR 396_ SKYKV 401_ NPIKV 406_ DPTMW 411_ DTIKN 416_ DVKDD 421_ RILIE 426_ FDTLK 431_ EMVIL 436_ AGKSE 441_ DVQSI 446_ EVQVR 451_ ELIES 456_ TTQKI 461_ KREEQ 466_ SLKEK 471_ MIISP 476_ GRYFL 481_ LCHSS 486_ LLDHL 491_ LTECP 496_ EIEIC 501_ YDRVT 506_ QHLCL 511_ KGPSA 516_ DVYKA 521_ KCEIQ 526_ EKVYT 531_ MAQKN 536_ IQVSP 541_ EIFQF 546_ LQQVN 551_ WKEFS 556_ KCLFI 561_ AQKIL 566_ ALYEL 571_ EGTTV 576_ LLTSC 581_ SSEAL 586_ LEAEK 591_ QMLSA 596_ LNYKR 601_ IEVEN 606_ KEVLH 611_ GKKWK 616_ GLTHN 621_ LLKKQ 626_ NSSPN 631_ TVIIN 636_ ELTSE 641_ TTAEV 646_ IITGC 651_ VKEVN 656_ ETYKL 661_ LFNFV 666_ EQNMK 671_ IERLV 676_ EVKPS 681_ LVIDY 686_ LKTEK 691_ KLFWP 696_ KIKKV 701_ NVQVS 706_ FNPEN 711_ KQKGI 716_ LLTGS 721_ KTEVL 726_ KAVDI 731_ VKQVW 736_ DSVCV 741_ KSVHT 746_ DKPGA 751_ KQFFQ 756_ DKARF 761_ YQSEI 766_ KRLFG 771_ CYIEL 776_ QENEV 781_ MKEGG 786_ SPAGQ 791_ KCFSR 796_ TVLAP 801_ GVVLI 806_ VQQGD 811_ LARLP 816_ VDVVV 821_ NASNE 826_ DLKHY 831_ GGLAA 836_ ALSKA 841_ AGPEL 846_ QADCD 851_ QIVKR 856_ EGRLL 861_ PGNAT 866_ ISKAG 871_ KLPYH 876_ HVIHA 881_ VGPRW 886_ SGYEA 891_ PRCVY 896_ LLRRA 901_ VQLSL 906_ CLAEK 911_ YKYRS 916_ IAIPA 921_ ISSGV 926_ FGFPL 931_ GRCVE 936_ TIVSA 941_ IKENF 946_ QFKKD 951_ GHCLK 956_ EIYLV 961_ DVSEK 966_ TVEAF 971_ AEAVK 976_ TVFKA 981_ TLPDT 986_ AAPPG 991_ LPPAA 996_ AGPGK 1001_ TSWEK 1006_ GSLVS 1011_ PGGLQ 1016_ MLLVK 1021_ EGVQN 1026_ AKTDV 1031_ VVNSV 1036_ PLDLV 1041_ LSRGP 1046_ LSKSL 1051_ LEKAG 1056_ PELQE 1061_ ELDTV 1066_ GQGVA 1071_ VSMGT 1076_ VLKTS 1081_ SWNLD 1086_ CRYVL 1091_ HVVAP 1096_ EWRNG 1101_ STSSL 1106_ KIMED 1111_ IIREC 1116_ MEITE 1121_ SLSLK 1126_ SIAFP 1131_ AIGTG 1136_ NLGFP 1141_ KNIFA 1146_ ELIIS 1151_ EVFKF 1156_ SSKNQ 1161_ LKTLQ 1166_ EVHFL 1171_ LHPSD 1176_ HENIQ 1181_ AFSDE 1186_ FARRA 1191_ NGNLV 1196_ SDKIP 1201_ KAKDT 1206_ QGFYG 1211_ TVSSP 1216_ DSGVY 1221_ EMKIG 1226_ SIIFQ 1231_ VASGD 1236_ ITKEE 1241_ ADVIV 1246_ NSTSN 1251_ SFNLK 1256_ AGVSK 1261_ AILEC 1266_ AGQNV 1271_ ERECS 1276_ QQAQQ 1281_ RKNDY 1286_ IITGG 1291_ GFLRC 1296_ KNIIH 1301_ VIGGN 1306_ DVKSS 1311_ VSSVL 1316_ QECEK 1321_ KNYSS 1326_ ICLPA 1331_ IGTGN 1336_ AKQHP 1341_ DKVAE 1346_ AIIDA 1351_ IEDFV 1356_ QKGSA 1361_ QSVKK 1366_ VKVVI 1371_ FLPQV 1376_ LDVFY 1381_ ANMKK 1386_ REGTQ 1391_ LSSQQ 1396_ SVMSK 1401_ LASFL 1406_ GFSKQ 1411_ SPQKK 1416_ NHLVL 1421_ EKKTE 1426_ SATFR 1431_ VCGEN 1436_ VTCVE 1441_ YAISW 1446_ LQDLI 1451_ EKEQC 1456_ PYTSE 1461_ DECIK 1466_ DFDEK 1471_ EYQEL 1476_ NELQK 1481_ KLNIN 1486_ ISLDH 1491_ KRPLI 1496_ KVLGI 1501_ SRDVM 1506_ QARDE 1511_ IEAMI 1516_ KRVRL 1521_ AKEQE 1526_ SRADC 1531_ ISEFI 1536_ EWQYN 1541_ DNNTS 1546_ HCFNK 1551_ MTNLK 1556_ LEDAR 1561_ REKKK 1566_ TVDVK 1571_ INHRH 1576_ YTVNL 1581_ NTYTA 1586_ TDTKG 1591_ HSLSV 1596_ QRLTK 1601_ SKVDI 1606_ PAHWS 1611_ DMKQQ 1616_ NFCVV 1621_ ELLPS 1626_ DPEYN 1631_ TVASK 1636_ FNQTC 1641_ SHFRI 1646_ EKIER 1651_ IQNPD 1656_ LWNSY 1661_ QAKKK 1666_ TMDAK 1671_ NGQTM 1676_ NEKQL 1681_ FHGTD 1686_ AGSVP 1691_ HVNRN 1696_ GFNRS 1701_ YAGKN 1706_ AVAYG 1711_ KGTYF 1716_ AVNAN 1721_ YSAND 1726_ TYSRP 1731_ DANGR 1736_ KHVYY 1741_ VRVLT 1746_ GIYTH 1751_ GNHSL 1756_ IVPPS 1761_ KNPQN 1766_ PTDLY 1771_ DTVTD 1776_ NVHHP 1781_ SLFVA 1786_ FYDYQ 1791_ AYPEY 1796_LITFR
1: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:18851833, PubMed:25043379, PubMed:27796300). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300)