Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)
1_MGNSH 6_ CVPQA 11_ PRRLR 16_ ASFSR 21_ KPSLK 26_ GNRED 31_ SARMS 36_ AGLPG 41_ PEAAR 46_ SGDAA 51_ ANKLF 56_ HYIPG 61_ TDILD 66_ LENQR 71_ ENLEQ 76_ PFLSV 81_ FKKGR 86_ RRVPV 91_ RNLGK 96_ VVHYA 101_ KVQLR 106_ FQHSQ 111_ DVSDC 116_ YLELF 121_ PAHLY 126_ FQAHG 131_ SEGLT 136_ FQGLL 141_ PLTEL 146_ SVCPL 151_ EGSRE 156_ HAFQI 161_ TGPLP 166_ APLLV 171_ LCPSR 176_ AELDR 181_ WLYHL 186_ EKQTA 191_ LLGGP 196_ RRCHS 201_ APPQR 206_ RLTRL 211_ RTASG 216_ HEPGG 221_ SAVCA 226_ SRVKL 231_ QHLPA 236_ QEQWD 241_ RLLVL 246_ YPTSL 251_ AIFSE 256_ ELDGL 261_ CFKGE 266_ LPLRA 271_ VHINL 276_ EEKEK 281_ QIRSF 286_ LIEGP 291_ LINTI 296_ RVVCA 301_ SYEDY 306_ GHWLL 311_ CLRAV 316_ THREG 321_ APPLP 326_ GAESF 331_ PGSQV 336_ MGSGR 341_ GSLSS 346_ GGQTS 351_ WDSGC 356_ LAPPS 361_ TRTSH 366_ SLPES 371_ SVPST 376_ VGCSS 381_ QHTPD 386_ QANSD 391_ RASIG 396_ RRRTE 401_ LRRSG 406_ SSRSP 411_ GSKAR 416_ AEGRG 421_ PVTPL 426_ HLDLT 431_ QLHRL 436_ SLESS 441_ PDAPD 446_ HTSET 451_ SHSPL 456_ YADPY 461_ TPPAT 466_ SHRRV 471_ TDVRG 476_ LEEFL 481_ SAMQS 486_ ARGPT 491_ PSSPL 496_ PSVPV 501_ SVPAS 506_ DPRSC 511_ SSGPA 516_ GPYLL 521_ SKKGA 526_ LQSRA 531_ AQRHR 536_ GSAKD 541_ GGPQP 546_ PDAPQ 551_ LVSSA 556_ REGSP 561_ EPWLP 566_ LTDGR 571_ SPRRS 576_ RDPGY 581_ DHLWD 586_ ETLSS 591_ SHQKC 596_ PQLGG 601_ PEASG 606_GLVQW
1: Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (By similarity) (PubMed:29531808)