T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
1_MRWCL 6_ LLIWA 11_ QGLRQ 16_ APLAS 21_ GMMTG 26_ TIETT 31_ GNISA 36_ EKGGS 41_ IILQC 46_ HLSST 51_ TAQVT 56_ QVNWE 61_ QQDQL 66_ LAICN 71_ ADLGW 76_ HISPS 81_ FKDRV 86_ APGPG 91_ LGLTL 96_ QSLTV 101_ NDTGE 106_ YFCIY 111_ HTYPD 116_ GTYTG 121_ RIFLE 126_ VLESS 131_ VAEHG 136_ ARFQI 141_ PLLGA 146_ MAATL 151_ VVICT 156_ AVIVV 161_ VALTR 166_ KKKAL 171_ RIHSV 176_ EGDLR 181_ RKSAG 186_ QEEWS 191_ PSAPS 196_ PPGSC 201_ VQAEA 206_ APAGL 211_ CGEQR 216_ GEDCA 221_ ELHDY 226_ FNVLS 231_ YRSLG 236_NCSFF
1: Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells (PubMed:19011627). Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116). Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity (PubMed:32503945)