Probable E3 SUMO-protein ligase RNF212 (EC 2.3.2.-) (Probable E3 SUMO-protein transferase RNF212) (RING finger protein 212)
1_MANWV 6_ FCNRC 11_ FQPPH 16_ RTSCF 21_ SLTNC 26_ GHVYC 31_ DACLG 36_ KGKKN 41_ ECLIC 46_ KAPCR 51_ TVLLS 56_ KHTDA 61_ DIQAF 66_ FMSID 71_ SLCKK 76_ YSRET 81_ SQILE 86_ FQEKH 91_ RKRLL 96_ AFYRE 101_ KISRL 106_ EESLR 111_ KSVLQ 116_ IEQLQ 121_ SMRSS 126_ QQTAF 131_ STIKS 136_ SVSTK 141_ PHGCL 146_ LPPHS 151_ SAPDR 156_ LESME 161_ VDLSP 166_ SPIRK 171_ SEIAA 176_ GPARI 181_ SMISP 186_ PQDGR 191_ MGPHL 196_ TASFC 201_ FIPWL 206_ TLSKP 211_ PVPGE 216_ CVISR 221_ GSPCF 226_ CIDVC 231_ PHWLL 236_ LLAFS 241_ SGRHG 246_ ELTNS 251_ KTLPI 256_ YAEVQ 261_ RAVLF 266_ PFQQA 271_ EGTLD 276_ TFRTP 281_ AVSVV 286_ FPLCQ 291_FERKK
1: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity)