Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]
1_MGKSE 6_ GPVGM 11_ VESAG 16_ RAGQK 21_ RPGFL 26_ EGGLL 31_ LLLLL 36_ VTAAL 41_ VALGV 46_ LYADR 51_ RGKQL 56_ PRLAS 61_ RLCFL 66_ QEERT 71_ FVKRK 76_ PRGIP 81_ EAQEV 86_ SEVCT 91_ TPGCV 96_ IAAAR 101_ ILQNM 106_ DPTTE 111_ PCDDF 116_ YQFAC 121_ GGWLR 126_ RHVIP 131_ ETNSR 136_ YSIFD 141_ VLRDE 146_ LEVIL 151_ KAVLE 156_ NSTAK 161_ DRPAV 166_ EKART 171_ LYRSC 176_ MNQSV 181_ IEKRG 186_ SQPLL 191_ DILEV 196_ VGGWP 201_ VAMDR 206_ WNETV 211_ GLEWE 216_ LERQL 221_ ALMNS 226_ QFNRR 231_ VLIDL 236_ FIWND 241_ DQNSS 246_ RHIIY 251_ IDQPT 256_ LGMPS 261_ REYYF 266_ NGGSN 271_ RKVRE 276_ AYLQF 281_ MVSVA 286_ TLLRE 291_ DANLP 296_ RDSCL 301_ VQEDM 306_ VQVLE 311_ LETQL 316_ AKATV 321_ PQEER 326_ HDVIA 331_ LYHRM 336_ GLEEL 341_ QSQFG 346_ LKGFN 351_ WTLFI 356_ QTVLS 361_ SVKIK 366_ LLPDE 371_ EVVVY 376_ GIPYL 381_ QNLEN 386_ IIDTY 391_ SARTI 396_ QNYLV 401_ WRLVL 406_ DRIGS 411_ LSQRF 416_ KDTRV 421_ NYRKA 426_ LFGTM 431_ VEEVR 436_ WRECV 441_ GYVNS 446_ NMENA 451_ VGSLY 456_ VREAF 461_ PGDSK 466_ SMVRE 471_ LIDKV 476_ RTVFV 481_ ETLDE 486_ LGWMD 491_ EESKK 496_ KAQEK 501_ AMSIR 506_ EQIGH 511_ PDYIL 516_ EEMNR 521_ RLDEE 526_ YSNLN 531_ FSEDL 536_ YFENS 541_ LQNLK 546_ VGAQR 551_ SLRKL 556_ REKVD 561_ PNLWI 566_ IGAAV 571_ VNAFY 576_ SPNRN 581_ QIVFP 586_ AGILQ 591_ PPFFS 596_ KEQPQ 601_ ALNFG 606_ GIGMV 611_ IGHEI 616_ THGFD 621_ DNGRN 626_ FDKNG 631_ NMMDW 636_ WSNFS 641_ TQHFR 646_ EQSEC 651_ MIYQY 656_ GNYSW 661_ DLADE 666_ QNVNG 671_ FNTLG 676_ ENIAD 681_ NGGVR 686_ QAYKA 691_ YLKWM 696_ AEGGK 701_ DQQLP 706_ GLDLT 711_ HEQLF 716_ FINYA 721_ QVWCG 726_ SYRPE 731_ FAIQS 736_ IKTDV 741_ HSPLK 746_ YRVLG 751_ SLQNL 756_ AAFAD 761_ TFHCA 766_ RGTPM 771_HPKER
1: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity)