Synaptic vesicle glycoprotein 2C
1_MEDSY 6_ KDRTS 11_ LMKGA 16_ KDIAR 21_ EVKKQ 26_ TVKKV 31_ NQAVD 36_ RAQDE 41_ YTQRS 46_ YSRFQ 51_ DEEDD 56_ DDYYP 61_ AGETY 66_ NGEAN 71_ DDEGS 76_ SEATE 81_ GHDED 86_ DEIYE 91_ GEYQG 96_ IPSMN 101_ QAKDS 106_ IVSVG 111_ QPKGD 116_ EYKDR 121_ RELES 126_ ERRAD 131_ EEELA 136_ QQYEL 141_ IIQEC 146_ GHGRF 151_ QWALF 156_ FVLGM 161_ ALMAD 166_ GVEVF 171_ VVGFV 176_ LPSAE 181_ TDLCI 186_ PNSGS 191_ GWLGS 196_ IVYLG 201_ MMVGA 206_ FFWGG 211_ LADKV 216_ GRKQS 221_ LLICM 226_ SVNGF 231_ FAFLS 236_ SFVQG 241_ YGFFL 246_ FCRLL 251_ SGFGI 256_ GGAIP 261_ TVFSY 266_ FAEVL 271_ AREKR 276_ GEHLS 281_ WLCMF 286_ WMIGG 291_ IYASA 296_ MAWAI 301_ IPHYG 306_ WSFSM 311_ GSAYQ 316_ FHSWR 321_ VFVIV 326_ CALPC 331_ VSSVV 336_ ALTFM 341_ PESPR 346_ FLLEV 351_ GKHDE 356_ AWMIL 361_ KLIHD 366_ TNMRA 371_ RGQPE 376_ KVFTV 381_ NKIKT 386_ PKQID 391_ ELIEI 396_ ESDTG 401_ TWYRR 406_ CFVRI 411_ RTELY 416_ GIWLT 421_ FMRCF 426_ NYPVR 431_ DNTIK 436_ LTIVW 441_ FTLSF 446_ GYYGL 451_ SVWFP 456_ DVIKP 461_ LQSDE 466_ YALLT 471_ RNVER 476_ DKYAN 481_ FTINF 486_ TMENQ 491_ IHTGM 496_ EYDNG 501_ RFIGV 506_ KFKSV 511_ TFKDS 516_ VFKSC 521_ TFEDV 526_ TSVNT 531_ YFKNC 536_ TFIDT 541_ VFDNT 546_ DFEPY 551_ KFIDS 556_ EFKNC 561_ SFFHN 566_ KTGCQ 571_ ITFDD 576_ DYSAY 581_ WIYFV 586_ NFLGT 591_ LAVLP 596_ GNIVS 601_ ALLMD 606_ RIGRL 611_ TMLGG 616_ SMVLS 621_ GISCF 626_ FLWFG 631_ TSESM 636_ MIGML 641_ CLYNG 646_ LTISA 651_ WNSLD 656_ VVTVE 661_ LYPTD 666_ RRATG 671_ FGFLN 676_ ALCKA 681_ AAVLG 686_ NLIFG 691_ SLVSI 696_ TKSIP 701_ ILLAS 706_ TVLVC 711_ GGLVG 716_ LCLPD 721_TRTQV
1: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles
2: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224). Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119)
3: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans