Putative oxidoreductase GLYR1 (EC 1.-.-.-) (3-hydroxyisobutyrate dehydrogenase-like protein) (Cytokine-like nuclear factor N-PAC) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF)
1_MAAVS 6_ LRLGD 11_ LVWGK 16_ LGRYP 21_ PWPGK 26_ IVNPP 31_ KDLKK 36_ PRGKK 41_ CFFVK 46_ FFGTE 51_ DHAWI 56_ KVEQL 61_ KPYHA 66_ HKEEM 71_ IKINK 76_ GKRFQ 81_ QAVDA 86_ VEEFL 91_ RRAKG 96_ KDQTS 101_ SHNSS 106_ DDKNR 111_ RNSSE 116_ ERSRP 121_ NSGDE 126_ KRKLS 131_ LSEGK 136_ VKKNM 141_ GEGKK 146_ RVSSG 151_ SSERG 156_ SKSPL 161_ KRAQE 166_ QSPRK 171_ RGRPP 176_ KDEKD 181_ LTIPE 186_ SSTVK 191_ GMMAG 196_ PMAAF 201_ KWQPT 206_ ASEPV 211_ KDADP 216_ HFHHF 221_ LLSQT 226_ EKPAV 231_ CYQAI 236_ TKKLK 241_ ICEEE 246_ TGSTS 251_ IQAAD 256_ STAVN 261_ GSITP 266_ TDKKI 271_ GFLGL 276_ GLMGS 281_ GIVSN 286_ LLKMG 291_ HTVTV 296_ WNRTA 301_ EKCDL 306_ FIQEG 311_ ARLGR 316_ TPAEV 321_ VSTCD 326_ ITFAC 331_ VSDPK 336_ AAKDL 341_ VLGPS 346_ GVLQG 351_ IRPGK 356_ CYVDM 361_ STVDA 366_ DTVTE 371_ LAQVI 376_ VSRGG 381_ RFLEA 386_ PVSGN 391_ QQLSN 396_ DGMLV 401_ ILAAG 406_ DRGLY 411_ EDCSS 416_ CFQAM 421_ GKTSF 426_ FLGEV 431_ GNAAK 436_ MMLIV 441_ NMVQG 446_ SFMAT 451_ IAEGL 456_ TLAQV 461_ TGQSQ 466_ QTLLD 471_ ILNQG 476_ QLASI 481_ FLDQK 486_ CQNIL 491_ QGNFK 496_ PDFYL 501_ KYIQK 506_ DLRLA 511_ IALGD 516_ AVNHP 521_ TPMAA 526_ AANEV 531_ YKRAK 536_ ALDQS 541_ DNDMS 546_AVYRA
1: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664)