Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)
1_MKWLG 6_ ESKNM 11_ VVNGR 16_ RNGGK 21_ LSNDH 26_ QQNQS 31_ KLQHT 36_ GKDTL 41_ KAGKN 46_ AVERR 51_ SNRCN 56_ GNSGF 61_ EGQSR 66_ YVPSS 71_ GMSAK 76_ ELCEN 81_ DDLAT 86_ SLVLD 91_ PYLGF 96_ QTHKM 101_ NTSAF 106_ PSRSS 111_ RHFSK 116_ SDSFS 121_ HNNPV 126_ RFRPI 131_ KGRQE 136_ ELKEV 141_ IERFK 146_ KDEHL 151_ EKAFK 156_ CLTSG 161_ EWARH 166_ YFLNK 171_ NKMQE 176_ KLFKE 181_ HVFIY 186_ LRMFA 191_ TDSGF 196_ EILPC 201_ NRYSS 206_ EQNGA 211_ KIVAT 216_ KEWKR 221_ NDKIE 226_ LLVGC 231_ IAELS 236_ EIEEN 241_ MLLRH 246_ GENDF 251_ SVMYS 256_ TRKNC 261_ AQLWL 266_ GPAAF 271_ INHDC 276_ RPNCK 281_ FVSTG 286_ RDTAC 291_ VKALR 296_ DIEPG 301_ EEISC 306_ YYGDG 311_ FFGEN 316_ NEFCE 321_ CYTCE 326_ RRGTG 331_ AFKSR 336_ VGLPA 341_ PAPVI 346_ NSKYG 351_ LRETD 356_ KRLNR 361_ LKKLG 366_ DSSKN 371_ SDSQS 376_ VSSNT 381_ DADTT 386_ QEKNN 391_ ATSNR 396_ KSSVG 401_ VKKNS 406_ KSRTL 411_ TRQSM 416_ SRIPA 421_ SSNST 426_ SSKLT 431_ HINNS 436_ RVPKK 441_ LKKPA 446_ KPLLS 451_ KIKLR 456_ NHCKR 461_ LEQKN 466_ ASRKL 471_ EMGNL 476_ VLKEP 481_ KVVLY 486_ KNLPI 491_ KKDKE 496_ PEGPA 501_ QAAVA 506_ SGCLT 511_ RHAAR 516_ EHRQN 521_ PVRGA 526_ HSQGE 531_ SSPCT 536_ YITRR 541_ SVRTR 546_ TNLKE 551_ ASDIK 556_ LEPNT 561_ LNGYK 566_ SSVTE 571_ PCPDS 576_ GEQLQ 581_ PAPVL 586_ QEEEL 591_ AHETA 596_ QKGEA 601_ KCHKS 606_ DTGMS 611_ KKKSR 616_ QGKLV 621_ KQFAK 626_ IEEST 631_ PVHDS 636_ PGKDD 641_ AVPDL 646_ MGPHS 651_ DQGEH 656_ SGTVG 661_ VPVSY 666_ TDCAP 671_ SPVGC 676_ SVVTS 681_ DSFKT 686_ KDSFR 691_ TAKSK 696_ KKRRI 701_ TRYDA 706_ QLILE 711_ NNSGI 716_ PKLTL 721_ RRRHD 726_ SSSKT 731_ NDQEN 736_ DGMNS 741_ SKISI 746_ KLSKD 751_ HDNDN 756_ NLYVA 761_ KLNNG 766_ FNSGS 771_ GSSST 776_ KLKIQ 781_ LKRDE 786_ ENRGS 791_ YTEGL 796_ HENGV 801_ CCSDP 806_ LSLLE 811_ SRMEV 816_ DDYSQ 821_ YEEES 826_ TDDSS 831_ SSEGD 836_ EEEDD 841_ YDDDF 846_ EDDFI 851_ PLPPA 856_ KRLRL 861_ IVGKD 866_ SIDID 871_ ISSRR 876_REDQS
1: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)