Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)
1_MSFFG 6_ FGQSV 11_ EVEIL 16_ LNDAE 21_ SRKRA 26_ EHKTE 31_ DGKKE 36_ KYFLF 41_ YDGET 46_ VSGKV 51_ SLALK 56_ NPNKR 61_ LEHQG 66_ IKIEF 71_ IGQIE 76_ LYYDR 81_ GNHHE 86_ FVSLV 91_ KDLAR 96_ PGEIT 101_ QSQAF 106_ DFEFT 111_ HVEKP 116_ YESYT 121_ GQNVK 126_ LRYFL 131_ RATIS 136_ RRLND 141_ VVKEM 146_ DIVVH 151_ TLSTY 156_ PELNS 161_ SIKME 166_ VGIED 171_ CLHIE 176_ FEYNK 181_ SKYHL 186_ KDVIV 191_ GKIYF 196_ LLVRI 201_ KIKHM 206_ EIDII 211_ KRETT 216_ GTGPN 221_ VYHEN 226_ DTIAK 231_ YEIMD 236_ GAPVR 241_ GESIP 246_ IRLFL 251_ AGYEL 256_ TPTMR 261_ DINKK 266_ FSVRY 271_ YLNLV 276_ LIDEE 281_ ERRYF 286_ KQQEV 291_ VLWRK 296_ GDIVR 301_ KSMSH 306_ QAAIA 311_ SQRFE 316_ GTTSL 321_ GEVRT 326_ PSQLS 331_DNNCR
1: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity)