La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
1_METES 6_ GNQEK 11_ VMEEE 16_ STEKK 21_ KEVEK 26_ KKRSR 31_ VKQVL 36_ ADIAK 41_ QVDFW 46_ FGDAN 51_ LHKDR 56_ FLREQ 61_ IEKSR 66_ DGYVD 71_ ISLLV 76_ SFNKM 81_ KKLTT 86_ DGKLI 91_ ARALR 96_ SSAVV 101_ ELDLE 106_ GTRIR 111_ RKKPL 116_ GERPK 121_ DEDER 126_ TVYVE 131_ LLPKN 136_ VNHSW 141_ IERVF 146_ GKCGN 151_ VVYIS 156_ IPHYK 161_ STGDP 166_ KGFAF 171_ VEFET 176_ KEQAA 181_ KAIEF 186_ LNNPP 191_ EEAPR 196_ KPGIF 201_ PKTVK 206_ NKPIP 211_ ALRVV 216_ EEKKK 221_ KKKKK 226_ GRMKK 231_ EDNIQ 236_ AKEEN 241_ MDTSN 246_ TSISK 251_ MKRSR 256_ PTSEG 261_ SDIES 266_ TEPQK 271_ QCSKK 276_ KKKRD 281_ RVEAS 286_ SLPEV 291_ RTGKR 296_ KRSSS 301_ EDAES 306_ LAPRS 311_ KVKKI 316_ IQKDI 321_ IKEAS 326_ EASKE 331_ NRDIE 336_ ISTEE 341_ EKDTG 346_ DLKDS 351_ SLLKT 356_ KRKHK 361_ KKHKE 366_ RHKMG 371_ EEVIP 376_ LRVLS 381_ KSEWM 386_ DLKKE 391_ YLALQ 396_ KASMA 401_ SLKKT 406_ ISQIK 411_ SESEM 416_ ETDSG 421_ VPQNT 426_ GMKNE 431_ KTANR 436_ EECRT 441_ QEKVN 446_ ATGPQ 451_ FVSGV 456_ IVKII 461_ STEPL 466_ PGRKQ 471_ VRDTL 476_ AAISE 481_ VLYVD 486_ LLEGD 491_ TECHA 496_ RFKTP 501_ EDAQA 506_ VINAY 511_ TEINK 516_ KHCWK 521_ LEILS 526_ GDHEQ 531_ RYWQK 536_ ILVDR 541_ QAKLN 546_ QPREK 551_ KRGTE 556_ KLITK 561_ AEKIR 566_ LAKTQ 571_ QASKH 576_IRFSE
1: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity)