Erythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin)
1_MAPAR 6_ RPAGA 11_ RLLLV 16_ YAGLL 21_ AAAAA 26_ GLGSP 31_ EPGAP 36_ SRSRA 41_ RREPP 46_ PGNEL 51_ PRGPG 56_ ESRAG 61_ PAARP 66_ PEPTA 71_ ERAHS 76_ VDPRD 81_ AWMLF 86_ VRQSD 91_ KGVNG 96_ KKRSR 101_ GKAKK 106_ LKFGL 111_ PGPPG 116_ PPGPQ 121_ GPPGP 126_ IIPPE 131_ ALLKE 136_ FQLLL 141_ KGAVR 146_ QRERA 151_ EPEPC 156_ TCGPA 161_ GPVAA 166_ SLAPV 171_ SATAG 176_ EDDDD 181_ VVGDV 186_ LALLA 191_ APLAP 196_ GPRAP 201_ RVEAA 206_ FLCRL 211_ RRDAL 216_ VERRA 221_ LHELG 226_ VYYLP 231_ DAEGA 236_ FRRGP 241_ GLNLT 246_ SGQYR 251_ APVAG 256_ FYALA 261_ ATLHV 266_ ALGEP 271_ PRRGP 276_ PRPRD 281_ HLRLL 286_ ICIQS 291_ RCQRN 296_ ASLEA 301_ IMGLE 306_ SSSEL 311_ FTISV 316_ NGVLY 321_ LQMGQ 326_ WTSVF 331_ LDNAS 336_ GCSLT 341_ VRSGS 346_HFSAV
1: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (By similarity). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (By similarity). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity)