Gene name: KCTD21

Uniprot entry:

Q4G0X4

Protein names:

BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)

Protein sequence:

1_MSDPI 6_ TLNVG 11_ GKLYT 16_ TSLAT 21_ LTSFP 26_ DSMLG 31_ AMFSG 36_ KMPTK 41_ RDSQG 46_ NCFID 51_ RDGKV 56_ FRYIL 61_ NFLRT 66_ SHLDL 71_ PEDFQ 76_ EMGLL 81_ RREAD 86_ FYQVQ 91_ PLIEA 96_ LQEKE 101_ VELSK 106_ AEKNA 111_ MLNIT 116_ LNQRV 121_ QTVHF 126_ TVREA 131_ PQIYS 136_ LSSSS 141_ MEVFN 146_ ANIFS 151_ TSCLF 156_ LKLLG 161_ SKLFY 166_ CSNGN 171_ LSSIT 176_ SHLQD 181_ PNHLT 186_ LDWVA 191_ NVEGL 196_ PEEEY 201_ TKQNL 206_ KRLWV 211_ VPANK 216_ QINSF 221_ QVFVE 226_ EVLKI 231_ ALSDG 236_ FCIDS 241_ SHPHA 246_ LDFMN 251_NKIIR

Protein annotations

Protein functions:

1: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142)