Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.n3) (Acyl-CoA synthetase family member 3)
1_MLPHV 6_ VLTFR 11_ RLGCA 16_ LASCR 21_ LAPAR 26_ HRGSG 31_ LLHTA 36_ PVARS 41_ DRSAP 46_ VFTRA 51_ LAFGD 56_ RIALV 61_ DQHGR 66_ HTYRE 71_ LYSRS 76_ LRLSQ 81_ EICRL 86_ CGCVG 91_ GDLRE 96_ ERVSF 101_ LCAND 106_ ASYVV 111_ AQWAS 116_ WMSGG 121_ VAVPL 126_ YRKHP 131_ AAQLE 136_ YVICD 141_ SQSSV 146_ VLASQ 151_ EYLEL 156_ LSPVV 161_ RKLGV 166_ PLLPL 171_ TPAIY 176_ TGAVE 181_ EPAEV 186_ PVPEQ 191_ GWRNK 196_ GAMII 201_ YTSGT 206_ TGRPK 211_ GVLST 216_ HQNIR 221_ AVVTG 226_ LVHKW 231_ AWTKD 236_ DVILH 241_ VLPLH 246_ HVHGV 251_ VNALL 256_ CPLWV 261_ GATCV 266_ MMPEF 271_ SPQQV 276_ WEKFL 281_ SSETP 286_ RINVF 291_ MAVPT 296_ IYTKL 301_ MEYYD 306_ RHFTQ 311_ PHAQD 316_ FLRAV 321_ CEEKI 326_ RLMVS 331_ GSAAL 336_ PLPVL 341_ EKWKN 346_ ITGHT 351_ LLERY 356_ GMTEI 361_ GMALS 366_ GPLTT 371_ AVRLP 376_ GSVGT 381_ PLPGV 386_ QVRIV 391_ SENPQ 396_ REACS 401_ YTIHA 406_ EGDER 411_ GTKVT 416_ PGFEE 421_ KEGEL 426_ LVRGP 431_ SVFRE 436_ YWNKP 441_ EETKS 446_ AFTLD 451_ GWFKT 456_ GDTVV 461_ FKDGQ 466_ YWIRG 471_ RTSVD 476_ IIKTG 481_ GYKVS 486_ ALEVE 491_ WHLLA 496_ HPSIT 501_ DVAVI 506_ GVPDM 511_ TWGQR 516_ VTAVV 521_ TLREG 526_ HSLSH 531_ RELKE 536_ WARNV 541_ LAPYA 546_ VPSEL 551_ VLVEE 556_ IPRNQ 561_ MGKID 566_ KKALI 571_RHFHP
1: Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21841779, PubMed:21846720). May have some preference toward very-long-chain substrates (PubMed:17762044)