Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)
1_MKKMS 6_ RNVLL 11_ QMEEE 16_ EDDDD 21_ GDIVL 26_ ENLGQ 31_ TIVPD 36_ LGSLE 41_ SQHDF 46_ RTPEF 51_ EEFNG 56_ KPDSL 61_ FFNDG 66_ QRRID 71_ FVLVY 76_ EDESR 81_ KETNK 86_ KGTNE 91_ KQRRK 96_ RQAYE 101_ SNLIC 106_ HGLQL 111_ EATRS 116_ VLDDK 121_ LVFVK 126_ VHAPW 131_ EVLCT 136_ YAEIM 141_ HIKLP 146_ LKPND 151_ LKNRS 156_ SAFGT 161_ LNWFT 166_ KVLSV 171_ DESII 176_ KPEQE 181_ FFTAP 186_ FEKNR 191_ MNDFY 196_ IVDRD 201_ AFFNP 206_ ATRSR 211_ IVYFI 216_ LSRVK 221_ YQVIN 226_ NVSKF 231_ GINRL 236_ VNSGI 241_ YKAAF 246_ PLHDC 251_ KFRRQ 256_ SEDPS 261_ CPNER 266_ YLLYR 271_ EWAHP 276_ RSIYK 281_ KQPLD 286_ LIRKY 291_ YGEKI 296_ GIYFA 301_ WLGYY 306_ TQMLL 311_ LAAVV 316_ GVACF 321_ LYGYL 326_ NQDNC 331_ TWSKE 336_ VCHPD 341_ IGGKI 346_ IMCPQ 351_ CDRLC 356_ PFWKL 361_ NITCE 366_ SSKKL 371_ CIFDS 376_ FGTLV 381_ FAVFM 386_ GVWVT 391_ LFLEF 396_ WKRRQ 401_ AELEY 406_ EWDTV 411_ ELQQE 416_ EQARP 421_ EYEAR 426_ CTHVV 431_ INEIT 436_ QEEER 441_ IPFTA 446_ WGKCI 451_ RITLC 456_ ASAVF 461_ FWILL 466_ IIASV 471_ IGIIV 476_ YRLSV 481_ FIVFS 486_ AKLPK 491_ NINGT 496_ DPIQK 501_ YLTPQ 506_ TATSI 511_ TASII 516_ SFIII 521_ MILNT 526_ IYEKV 531_ AIMIT 536_ NFELP 541_ RTQTD 546_ YENSL 551_ TMKMF 556_ LFQFV 561_ NYYSS 566_ CFYIA 571_ FFKGK 576_ FVGYP 581_ GDPVY 586_ WLGKY 591_ RNEEC 596_ DPGGC 601_ LLELT 606_ TQLTI 611_ IMGGK 616_ AIWNN 621_ IQEVL 626_ LPWIM 631_ NLIGR 636_ FHRVS 641_ GSEKI 646_ TPRWE 651_ QDYHL 656_ QPMGK 661_ LGLFY 666_ EYLEM 671_ IIQFG 676_ FVTLF 681_ VASFP 686_ LAPLL 691_ ALVNN 696_ ILEIR 701_ VDAWK 706_ LTTQF 711_ RRLVP 716_ EKAQD 721_ IGAWQ 726_ PIMQG 731_ IAILA 736_ VVTNA 741_ MIIAF 746_ TSDMI 751_ PRLVY 756_ YWSFS 761_ VPPYG 766_ DHTSY 771_ TMEGY 776_ INNTL 781_ SIFKV 786_ ADFKN 791_ KSKGN 796_ PYSDL 801_ GNHTT 806_ CRYRD 811_ FRYPP 816_ GHPQE 821_ YKHNI 826_ YYWHV 831_ IAAKL 836_ AFIIV 841_ MEHVI 846_ YSVKF 851_ FISYA 856_ IPDVS 861_ KRTKS 866_ KIQRE 871_ KYLTQ 876_ KLLHE 881_ NHLKD 886_ MTKNM 891_ GVIAE 896_ RMIEA 901_VDNNL
1: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity)
2: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia