Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)
1_MAFND 6_ LLQQV 11_ GGVGR 16_ FQQIQ 21_ VTLVV 26_ LPLLL 31_ MASHN 36_ TLQNF 41_ TAAIP 46_ THHCR 51_ PPADA 56_ NLSKN 61_ GGLEV 66_ WLPRD 71_ RQGQP 76_ ESCLR 81_ FTSPQ 86_ WGLPF 91_ LNGTE 96_ ANGTG 101_ ATEPC 106_ TDGWI 111_ YDNST 116_ FPSTI 121_ VTEWD 126_ LVCSH 131_ RALRQ 136_ LAQSL 141_ YMVGV 146_ LLGAM 151_ VFGYL 156_ ADRLG 161_ RRKVL 166_ ILNYL 171_ QTAVS 176_ GTCAA 181_ FAPNF 186_ PIYCA 191_ FRLLS 196_ GMALA 201_ GISLN 206_ CMTLN 211_ VEWMP 216_ IHTRA 221_ CVGTL 226_ IGYVY 231_ SLGQF 236_ LLAGV 241_ AYAVP 246_ HWRHL 251_ QLLVS 256_ APFFA 261_ FFIYS 266_ WFFIE 271_ SARWH 276_ SSSGR 281_ LDLTL 286_ RALQR 291_ VARIN 296_ GKREE 301_ GAKLS 306_ MEVLR 311_ ASLQK 316_ ELTMG 321_ KGQAS 326_ AMELL 331_ RCPTL 336_ RHLFL 341_ CLSML 346_ WFATS 351_ FAYYG 356_ LVMDL 361_ QGFGV 366_ SIYLI 371_ QVIFG 376_ AVDLP 381_ AKLVG 386_ FLVIN 391_ SLGRR 396_ PAQMA 401_ ALLLA 406_ GICIL 411_ LNGVI 416_ PQDQS 421_ IVRTS 426_ LAVLG 431_ KGCLA 436_ ASFNC 441_ IFLYT 446_ GELYP 451_ TMIRQ 456_ TGMGM 461_ GSTMA 466_ RVGSI 471_ VSPLV 476_ SMTAE 481_ LYPSM 486_ PLFIY 491_ GAVPV 496_ AASAV 501_ TVLLP 506_ ETLGQ 511_ PLPDT 516_ VQDLE 521_ SRWAP 526_ TQKEA 531_ GIYPR 536_ KGKQT 541_ RQQQE 546_ HQKYM 551_ VPLQA 556_SAQEK
1: Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:11669456, PubMed:11907186, PubMed:14675047, PubMed:22108572, PubMed:23832370, PubMed:28534121, PubMed:9950961). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (PubMed:9887087). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:11907186). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:26377792). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:22108572, PubMed:23832370). May transport glutamate (PubMed:26377792). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:11669456, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate (PubMed:14675047, PubMed:26377792). Xenobiotics include the mycotoxin ochratoxin (OTA) (PubMed:11669456). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (PubMed:35307651)