Transmembrane protein 119 (Osteoblast induction factor) (OBIF)
1_MVSAA 6_ APSLL 11_ ILLLL 16_ LLGSV 21_ PATDA 26_ RSVPL 31_ KATFL 36_ EDVAG 41_ SGEAE 46_ GSSAS 51_ SPSLP 56_ PPWTP 61_ ALSPT 66_ SMGPQ 71_ PITLG 76_ GPSPP 81_ TNFLD 86_ GIVDF 91_ FRQYV 96_ MLIAV 101_ VGSLA 106_ FLLMF 111_ IVCAA 116_ VITRQ 121_ KQKAS 126_ AYYPS 131_ SFPKK 136_ KYVDQ 141_ SDRAG 146_ GPRAF 151_ SEVPD 156_ RAPDS 161_ RPEEA 166_ LDSSR 171_ QLQAD 176_ ILAAT 181_ QNLKS 186_ PTRAA 191_ LGGGD 196_ GARMV 201_ EGRGA 206_ EEEEK 211_ GSQEG 216_ DQEVQ 221_ GHGVP 226_ VETPE 231_ AQEEP 236_ CSGVL 241_ EGAVV 246_ AGEGQ 251_ GELEG 256_ SLLLA 261_ QEAQG 266_ PVGPP 271_ ESPCA 276_CSSVH
1: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity)