PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)
1_MNFEG 6_ LDPGL 11_ AEYAP 16_ AMHSA 21_ LDPVL 26_ DAHLN 31_ PSLLQ 36_ NVELD 41_ PEGVA 46_ LEALP 51_ VQESV 56_ HIMEG 61_ VYSEL 66_ HSVVA 71_ EVGVP 76_ VSVSH 81_ FDLHE 86_ EMLWV 91_ GSHGG 96_ HATSF 101_ FGPAL 106_ ERYSS 111_ FQVNG 116_ SDDIR 121_ QIQSL 126_ ENGIL 131_ FLTKN 136_ NLKYM 141_ ARGGL 146_ IIFDY 151_ LLDEN 156_ EDMHS 161_ LLLTD 166_ SSTLL 171_ VGGLQ 176_ NHIIE 181_ IDLNT 186_ VQETQ 191_ KYAVE 196_ TPGVT 201_ IMRQT 206_ NRFFF 211_ CGHTS 216_ GKVSL 221_ RDLRT 226_ FKVEH 231_ EFDAF 236_ SGSLS 241_ DFDVH 246_ GNLLA 251_ ACGFS 256_ SRLTG 261_ LACDR 266_ FLKVY 271_ DLRMM 276_ RAITP 281_ LQVHV 286_ DPAFL 291_ RFIPT 296_ YTSRL 301_ AIISQ 306_ SGQCQ 311_ FCEPT 316_ GLANP 321_ ADIFH 326_ VNPVG 331_ PLLMT 336_ FDVSA 341_ SKQAL 346_ AFGDS 351_ EGCVH 356_ LWTDS 361_ PEPSF 366_ NPYSR 371_ ETEFA 376_ LPCLV 381_ DSLPP 386_ LDWSQ 391_ DLLPL 396_ SLIPV 401_ PLTTD 406_ TLLSD 411_ WPAAN 416_ SAPAP 421_ RRAPP 426_ VDAEI 431_ LRTMK 436_ KVGFI 441_ GYAPN 446_ PRTRL 451_ RNQIP 456_ YRLKE 461_ SDSEF 466_ DSFSQ 471_ VTESP 476_ VGREE 481_ EPHLH 486_ MVSKK 491_ YRKVT 496_ IKYSK 501_ LGLED 506_ FDFKH 511_ YNKTL 516_ FAGLE 521_ PHIPN 526_ AYCNC 531_ MIQVL 536_ YFLEP 541_ VRCLI 546_ QNHLC 551_ QKEFC 556_ LACEL 561_ GFLFH 566_ MLDLS 571_ RGDPC 576_ QGNNF 581_ LRAFR 586_ TIPEA 591_ SALGL 596_ ILADS 601_ DEASG 606_ KGNLA 611_ RLIQR 616_ WNRFI 621_ LTQLH 626_ QDMQE 631_ LEIPQ 636_ AYRGA 641_ GGSSF 646_ CSSGD 651_ SVIGQ 656_ LFSCE 661_ MENCS 666_ LCRCG 671_ SETVR 676_ ASSTL 681_ LFTLS 686_ YPDGS 691_ KSDKT 696_ GKNYD 701_ FAQVL 706_ KRSIC 711_ LDQNT 716_ QAWCD 721_ TCEKY 726_ QPTIQ 731_ TRNIR 736_ HLPDI 741_ LVINC 746_ EVNSS 751_ KEADF 756_ WRMQA 761_ EVAFK 766_ MAVKK 771_ HGGEI 776_ SKNKE 781_ FALAD 786_ WKELG 791_ SPEGV 796_ LVCPS 801_ IEELK 806_ NVWLP 811_ FSIRM 816_ KMTKN 821_ KGLDV 826_ CNWTD 831_ GDEMQ 836_ WGPAR 841_ AEEEH 846_ GVYVY 851_ DLMAT 856_ VVHIL 861_ DSRTG 866_ GSLVA 871_ HIKVG 876_ ETYHQ 881_ RKEGV 886_ THQQW 891_ YLFND 896_ FLIEP 901_ IDKHE 906_ AVQFD 911_ MNWKV 916_ PAILY 921_ YVKRN 926_ LNSRY 931_ NLNIK 936_ NPIEA 941_ SVLLA 946_ EASLA 951_ RKQRK 956_ THTTF 961_ IPLML 966_ NEMPQ 971_ IGDLV 976_ GLDAE 981_ FVTLN 986_ EEEAE 991_ LRSDG 996_ TKSTI 1001_ KPSQM 1006_ SVARI 1011_ TCVRG 1016_ QGPNE 1021_ GIPFI 1026_ DDYIS 1031_ TQEQV 1036_ VDYLT 1041_ QYSGI 1046_ KPGDL 1051_ DAKIS 1056_ SKHLT 1061_ TLKST 1066_ YLKLR 1071_ FLIDI 1076_ GVKFV 1081_ GHGLQ 1086_ KDFRV 1091_ INLMV 1096_ PKDQV 1101_ LDTVY 1106_ LFHMP 1111_ RKRMI 1116_ SLRFL 1121_ AWYFL 1126_ DLKIQ 1131_ GETHD 1136_ SIEDA 1141_ RTALQ 1146_ LYRKY 1151_ LELSK 1156_ NGTEP 1161_ ESFHK 1166_ VLKGL 1171_ YEKGR 1176_ KMDWK 1181_ VPEPE 1186_ GQTSP 1191_ KNAAV 1196_FSSVL
1: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation