Midnolin (Midbrain nucleolar protein)
1_MEPQP 6_ GGARS 11_ CRRGA 16_ PGGAC 21_ ELGPA 26_ AEAAP 31_ MSLAI 36_ HSTTG 41_ TRYDL 46_ AVPPD 51_ ETVEG 56_ LRKRL 61_ SQRLK 66_ VPKER 71_ LALLH 76_ KDTRL 81_ SSGKL 86_ QEFGV 91_ GDGSK 96_ LTLVP 101_ TVEAG 106_ LMSQA 111_ SRPEQ 116_ SVMQA 121_ LESLT 126_ ETQVS 131_ DFLSG 136_ RSPLT 141_ LALRV 146_ GDHMM 151_ FVQLQ 156_ LAAQH 161_ APLQH 166_ RHVLA 171_ AAAAA 176_ AAARG 181_ DPSIA 186_ SPVSS 191_ PCRPV 196_ SSAAR 201_ VPPVP 206_ TSPSP 211_ ASPSP 216_ ITAGS 221_ FRSHA 226_ ASTTC 231_ PEQMD 236_ CSPTA 241_ SSSAS 246_ PGAST 251_ TSTPG 256_ ASPAP 261_ RSRKP 266_ GAVIE 271_ SFVNH 276_ APGVF 281_ SGTFS 286_ GTLHP 291_ NCQDS 296_ SGRPR 301_ RDIGT 306_ ILQIL 311_ NDLLS 316_ ATRHY 321_ QGMPP 326_ SLAQL 331_ RCHAQ 336_ CSPAS 341_ PAPDL 346_ APRTT 351_ SCEKL 356_ TAAPS 361_ ASLLQ 366_ GQSQI 371_ RMCKP 376_ PGDRL 381_ RQTEN 386_ RATRC 391_ KVERL 396_ QLLLQ 401_ QKRLR 406_ RKARR 411_ DARGP 416_ YHWSP 421_ SRKAG 426_ RSDSS 431_ SSGGG 436_ GSPSE 441_ ASGLG 446_ LDFED 451_ SVWKP 456_ EVNPD 461_IKSEF
1: Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion