Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)
1_MRRRR 6_ AAVAA 11_ GFCAS 16_ FLLGS 21_ VLNVL 26_ FAPGS 31_ EPPRP 36_ GQSPE 41_ PSPAP 46_ GPGRR 51_ GGRGE 56_ LARQI 61_ RARYE 66_ EVQRY 71_ SRGGP 76_ GPGAG 81_ RPERR 86_ RLMDL 91_ APGGP 96_ GLPRP 101_ RPPWA 106_ RPLSD 111_ GAPGW 116_ PPAPG 121_ PGSPG 126_ PGPRL 131_ GCAAL 136_ RNVSG 141_ AQYMG 146_ SGYTK 151_ AVYRV 156_ RLPGG 161_ AAVAL 166_ KAVDF 171_ SGHDL 176_ GSCVR 181_ EFGVR 186_ RGCYR 191_ LAAHK 196_ LLKEM 201_ VLLER 206_ LRHPN 211_ VLQLY 216_ GYCYQ 221_ DSEDI 226_ PDTLT 231_ TITEL 236_ GAPVE 241_ MIQLL 246_ QTSWE 251_ DRFRI 256_ CLSLG 261_ RLLHH 266_ LAHSP 271_ LGSVT 276_ LLDFR 281_ PRQFV 286_ LVDGE 291_ LKVTD 296_ LDDAR 301_ VEETP 306_ CAGST 311_ DCILE 316_ FPARN 321_ FTLPC 326_ SAQGW 331_ CEGMN 336_ EKRNL 341_ YNAYR 346_ FFFTY 351_ LLPHS 356_ APPSL 361_ RPLLD 366_ SIVNA 371_ TGELA 376_ WGVDE 381_ TLAQL 386_ EKVLH 391_ LYRSG 396_ QYLQN 401_ STASS 406_ STEYQ 411_ CIPDS 416_ TIPQE 421_ DYRCW 426_ PSYHH 431_ GSCLL 436_ SVFNL 441_ AEAVD 446_ VCESH 451_ AQCRA 456_ FVVTN 461_ QTTWT 466_ GRQLV 471_ FFKTG 476_ WSQVV 481_ PDPNK 486_TTYVK
1: Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity)