Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)
1_MDVEN 6_ EQILN 11_ VNPAD 16_ PDNLS 21_ DSLFS 26_ GDEEN 31_ AGTEE 36_ IKNEI 41_ NGNWI 46_ SASSI 51_ NEARI 56_ NAKAK 61_ RRLRK 66_ NSSRD 71_ SGRGD 76_ SVSDS 81_ GSDAL 86_ RSGLT 91_ VPTSP 96_ KGRLL 101_ DRRSR 106_ SGKGR 111_ GLPKK 116_ GGAGG 121_ KGVWG 126_ TPGQV 131_ YDVEE 136_ VDVKD 141_ PNYDD 146_ DQENC 151_ VYETV 156_ VLPLD 161_ ERAFE 166_ KTLTP 171_ IIQEY 176_ FEHGD 181_ TNEVA 186_ EMLRD 191_ LNLGE 196_ MKSGV 201_ PVLAV 206_ SLALE 211_ GKASH 216_ REMTS 221_ KLLSD 226_ LCGTV 231_ MSTTD 236_ VEKSF 241_ DKLLK 246_ DLPEL 251_ ALDTP 256_ RAPQL 261_ VGQFI 266_ ARAVG 271_ DGILC 276_ NTYID 281_ SYKGT 286_ VDCVQ 291_ ARAAL 296_ DKATV 301_ LLSMS 306_ KGGKR 311_ KDSVW 316_ GSGGG 321_ QQSVN 326_ HLVKE 331_ IDMLL 336_ KEYLL 341_ SGDIS 346_ EAEHC 351_ LKELE 356_ VPHFH 361_ HELVY 366_ EAIIM 371_ VLEST 376_ GESTF 381_ KMILD 386_ LLKSL 391_ WKSST 396_ ITVDQ 401_ MKRGY 406_ ERIYN 411_ EIPDI 416_ NLDVP 421_ HSYSV 426_ LERFV 431_ EECFQ 436_ AGIIS 441_ KQLRD 446_ LCPSR 451_ GRKRF 456_ VSEGD 461_GGRLK
1: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)