Nuclear cap-binding protein subunit 3 (Protein ELG)
1_MAAVR 6_ GLRVS 11_ VKAEA 16_ PAGPA 21_ LGLPS 26_ PEAES 31_ GVDRG 36_ EPEPM 41_ EVEEG 46_ ELEIV 51_ PVRRS 56_ LKELI 61_ PDTSR 66_ RYENK 71_ AGSFI 76_ TGIDV 81_ TSKEA 86_ IEKKE 91_ QRAKR 96_ FHFRS 101_ EVNLA 106_ QRNVA 111_ LDRDM 116_ MKKAI 121_ PKVRL 126_ ETIYI 131_ CGVDE 136_ MSTQD 141_ VFSYF 146_ KEYPP 151_ AHIEW 156_ LDDTS 161_ CNVVW 166_ LDEMT 171_ ATRAL 176_ INMSS 181_ LPAQD 186_ KIRSR 191_ DASED 196_ KSAEK 201_ RKKDK 206_ QEDSS 211_ DDDEA 216_ EEGEV 221_ EDENS 226_ SDVEL 231_ DTLSQ 236_ VEEES 241_ LLRND 246_ LRPAN 251_ KLAKG 256_ NRLFM 261_ RFATK 266_ DDKKE 271_ LGAAR 276_ RSQYY 281_ MKYGN 286_ PNYGG 291_ MKGIL 296_ SNSWK 301_ RRYHS 306_ RRIQR 311_ DVIKK 316_ RALIG 321_ DDVGL 326_ TSYKH 331_ RHSGL 336_ VNVPE 341_ EPIEE 346_ EEEEE 351_ EEEEE 356_ EEEED 361_ QDMDA 366_ DDRVV 371_ VEYHE 376_ ELPAL 381_ KQPRE 386_ RSASR 391_ RSSAS 396_ SSDSD 401_ EMDYD 406_ LELKM 411_ ISTPS 416_ PKKSM 421_ KMTMY 426_ ADEVE 431_ SQLKN 436_ IRNSM 441_ RADSV 446_ SSSNI 451_ KNRIG 456_ NKLPP 461_ EKFAD 466_ VRHLL 471_ DEKRQ 476_ HSRPR 481_ PPVSS 486_ TKSDI 491_ RQRLG 496_ KRPHS 501_ PEKAF 506_ SSNPV 511_ VRREP 516_ SSDVH 521_ SRLGV 526_ PRQDS 531_ KGLYA 536_ DTREK 541_ KSGNL 546_ WTRLG 551_ SAPKT 556_ KEKNT 561_ KKVDH 566_ RAPGA 571_ EEDDS 576_ ELQRA 581_ WGALI 586_ KEKEQ 591_ SRQKK 596_ SRLDN 601_ LPSLQ 606_ IEVSR 611_ESSSG
1: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858)