Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein)
1_MLAVH 6_ FDKPG 11_ GPENL 16_ YVKEV 21_ AKPSP 26_ GEGEV 31_ LLKVA 36_ ASALN 41_ RADLM 46_ QRQGQ 51_ YDPPP 56_ GASNI 61_ LGLEA 66_ SGHVA 71_ ELGPG 76_ CQGHW 81_ KIGDT 86_ AMALL 91_ PGGGQ 96_ AQYVT 101_ VPEGL 106_ LMPIP 111_ EGLTL 116_ TQAAA 121_ IPEAW 126_ LTAFQ 131_ LLHLV 136_ GNVQA 141_ GDYVL 146_ IHAGL 151_ SGVGT 156_ AAIQL 161_ TRMAG 166_ AIPLV 171_ TAGSQ 176_ KKLQM 181_ AEKLG 186_ AAAGF 191_ NYKKE 196_ DFSEA 201_ TLKFT 206_ KGAGV 211_ NLILD 216_ CIGGS 221_ YWEKN 226_ VNCLA 231_ LDGRW 236_ VLYGL 241_ MGGGD 246_ INGPL 251_ FSKLL 256_ FKRGS 261_ LITSL 266_ LRSRD 271_ NKYKQ 276_ MLVNA 281_ FTEQI 286_ LPHFS 291_ TEGPQ 296_ RLLPV 301_ LDRIY 306_ PVTEI 311_ QEAHK 316_ YMEAN 321_ KNIGK 326_IVLEL
1: Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281). Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281). Involved in the generation of reactive oxygen species (ROS) (PubMed:19349281)