Novel acetylcholine receptor chaperone
1_MASPR 6_ TVTIV 11_ ALSVA 16_ LGLFF 21_ VFMGT 26_ IKLTP 31_ RLSKD 36_ AYSEM 41_ KRAYK 46_ SYVRA 51_ LPLLK 56_ KMGIN 61_ SILLR 66_ KSIGA 71_ LEVAC 76_ GIVMT 81_ LVPGR 86_ PKDVA 91_ NFFLL 96_ LLVLA 101_ VLFFH 106_ QLVGD 111_ PLKRY 116_ AHALV 121_ FGILL 126_ TCRLL 131_ IARKP 136_ EDRSS 141_ EKKPL 146_ PGNAE 151_ EQPSL 156_ YEKAP 161_QGKVK
1: Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916)