ORM1-like protein 2 (Adoplin-2)
1_MNVGV 6_ AHSEV 11_ NPNTR 16_ VMNSR 21_ GIWLA 26_ YIILV 31_ GLLHM 36_ VLLSI 41_ PFFSI 46_ PVVWT 51_ LTNVI 56_ HNLAT 61_ YVFLH 66_ TVKGT 71_ PFETP 76_ DQGKA 81_ RLLTH 86_ WEQMD 91_ YGLQF 96_ TSSRK 101_ FLSIS 106_ PIVLY 111_ LLASF 116_ YTKYD 121_ AAHFL 126_ INTAS 131_ LLSVL 136_ LPKLP 141_ QFHGV 146_RVFGI
1: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)