Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)
1_MMKKN 6_ NSAKR 11_ GPQDG 16_ NQQPA 21_ PPEKV 26_ GWVRK 31_ FCGKG 36_ IFREI 41_ WKNRY 46_ VVLKG 51_ DQLYI 56_ SEKEV 61_ KDEKN 66_ IQEVF 71_ DLSDY 76_ EKCEE 81_ LRKSK 86_ SRSKK 91_ NHSKF 96_ TLAHS 101_ KQPGN 106_ TAPNL 111_ IFLAV 116_ SPEEK 121_ ESWIN 126_ ALNSA 131_ ITRAK 136_ NRILD 141_ EVTVE 146_ EDSYL 151_ AHPTR 156_ DRAKI 161_ QHSRR 166_ PPTRG 171_ HLMAV 176_ ASTST 181_ SDGML 186_ TLDLI 191_ QEEDP 196_ SPEEP 201_ TSCAE 206_ SFRVD 211_ LDKSV 216_ AQLAG 221_ SRRRA 226_ DSDRI 231_ QPSAD 236_ RASSL 241_ SRPWE 246_ KTDKG 251_ ATYTP 256_ QAPKK 261_ LTPTE 266_ KGRCA 271_ SLEEI 276_ LSQRD 281_ AASAR 286_ TLQLR 291_ AEEPP 296_ TPALP 301_ NPGQL 306_ SRIQD 311_ LVARK 316_ LEETQ 321_ ELLAE 326_ VQGLG 331_ DGKRK 336_ AKDPP 341_ RSPPD 346_ SESEQ 351_ LLLET 356_ ERLLG 361_ EASSN 366_ WSQAK 371_ RVLQE 376_ VRELR 381_ DLYRQ 386_ MDLQT 391_ PDSHL 396_ RQTTP 401_HSQYR
1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation