Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)
1_MESAL 6_ PAAGF 11_ LYWVG 16_ AGTVA 21_ YLALR 26_ ISYSL 31_ FTALR 36_ VWGVG 41_ NEAGV 46_ GPGLG 51_ EWAVV 56_ TGSTD 61_ GIGKS 66_ YAEEL 71_ AKHGM 76_ KVVLI 81_ SRSKD 86_ KLDQV 91_ SSEIK 96_ EKFKV 101_ ETRTI 106_ AVDFA 111_ SEDIY 116_ DKIKT 121_ GLAGL 126_ EIGIL 131_ VNNVG 136_ MSYEY 141_ PEYFL 146_ DVPDL 151_ DNVIK 156_ KMINI 161_ NILSV 166_ CKMTQ 171_ LVLPG 176_ MVERS 181_ KGAIL 186_ NISSG 191_ SGMLP 196_ VPLLT 201_ IYSAT 206_ KTFVD 211_ FFSQC 216_ LHEEY 221_ RSKGV 226_ FVQSV 231_ LPYFV 236_ ATKLA 241_ KIRKP 246_ TLDKP 251_ SPETF 256_ VKSAI 261_ KTVGL 266_ QSRTN 271_ GYLIH 276_ ALMGS 281_ IISNL 286_ PSWIY 291_ LKIVM 296_ NMNKS 301_ TRAHY 306_LKKTK
1: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation