U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K)
1_MSGRS 6_ KRESR 11_ GSTRG 16_ KRESE 21_ SRGSS 26_ GRVKR 31_ ERDRE 36_ REPEA 41_ ASSRG 46_ SPVRV 51_ KREFE 56_ PASAR 61_ EAPAS 66_ VVPFV 71_ RVKRE 76_ REVDE 81_ DSEPE 86_ REVRA 91_ KNGRV 96_ DSEDR 101_ RSRHC 106_ PYLDT 111_ INRSV 116_ LDFDF 121_ EKLCS 126_ ISLSH 131_ INAYA 136_ CLVCG 141_ KYFQG 146_ RGLKS 151_ HAYIH 156_ SVQFS 161_ HHVFL 166_ NLHTL 171_ KFYCL 176_ PDNYE 181_ IIDSS 186_ LEDIT 191_ YVLKP 196_ TFTKQ 201_ QIANL 206_ DKQAK 211_ LSRAY 216_ DGTTY 221_ LPGIV 226_ GLNNI 231_ KANDY 236_ ANAVL 241_ QALSN 246_ VPPLR 251_ NYFLE 256_ EDNYK 261_ NIKRP 266_ PGDIM 271_ FLLVQ 276_ RFGEL 281_ MRKLW 286_ NPRNF 291_ KAHVS 296_ PHEML 301_ QAVVL 306_ CSKKT 311_ FQITK 316_ QGDGV 321_ DFLSW 326_ FLNAL 331_ HSALG 336_ GTKKK 341_ KKTIV 346_ TDVFQ 351_ GSMRI 356_ FTKKL 361_ PHPDL 366_ PAEEK 371_ EQLLH 376_ NDEYQ 381_ ETMVE 386_ STFMY 391_ LTLDL 396_ PTAPL 401_ YKDEK 406_ EQLII 411_ PQVPL 416_ FNILA 421_ KFNGI 426_ TEKEY 431_ KTYKE 436_ NFLKR 441_ FQLTK 446_ LPPYL 451_ IFCIK 456_ RFTKN 461_ NFFVE 466_ KNPTI 471_ VNFPI 476_ TNVDL 481_ REYLS 486_ EEVQA 491_ VHKNT 496_ TYDLI 501_ ANIVH 506_ DGKPS 511_ EGSYR 516_ IHVLH 521_ HGTGK 526_ WYELQ 531_ DLQVT 536_ DILPQ 541_ MITLS 546_ EAYIQ 551_ IWKRR 556_DNDET
1: Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806)