Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)
1_MTVFF 6_ KTLRN 11_ HWKKT 16_ TAGLC 21_ LLTWG 26_ GHWLY 31_ GKHCD 36_ NLLRR 41_ AACQE 46_ AQVFG 51_ NQLIP 56_ PNAQV 61_ KKATV 66_ FLNPA 71_ ACKGK 76_ ARTLF 81_ EKNAA 86_ PILHL 91_ SGMDV 96_ TIVKT 101_ DYEGQ 106_ AKKLL 111_ ELMEN 116_ TDVII 121_ VAGGD 126_ GTLQE 131_ VVTGV 136_ LRRTD 141_ EATFS 146_ KIPIG 151_ FIPLG 156_ ETSSL 161_ SHTLF 166_ AESGN 171_ KVQHI 176_ TDATL 181_ AIVKG 186_ ETVPL 191_ DVLQI 196_ KGEKE 201_ QPVFA 206_ MTGLR 211_ WGSFR 216_ DAGVK 221_ VSKYW 226_ YLGPL 231_ KIKAA 236_ HFFST 241_ LKEWP 246_ QTHQA 251_ SISYT 256_ GPTER 261_ PPNEP 266_ EETPV 271_ QRPSL 276_ YRRIL 281_ RRLAS 286_ YWAQP 291_ QDALS 296_ QEVSP 301_ EVWKD 306_ VQLST 311_ IELSI 316_ TTRNN 321_ QLDPT 326_ SKEDF 331_ LNICI 336_ EPDTI 341_ SKGDF 346_ ITIGS 351_ RKVRN 356_ PKLHV 361_ EGTEC 366_ LQASQ 371_ CTLLI 376_ PEGAG 381_ GSFSI 386_ DSEEY 391_ EAMPV 396_ EVKLL 401_ PRKLQ 406_ FFCDP 411_ RKREQ 416_MLTSP
1: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762)