Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)]
1_MFAEA 6_ AKTTR 11_ PCGMA 16_ EFKEK 21_ PEAPT 26_ EQLDV 31_ ACGQE 36_ NLPVG 41_ AWPPG 46_ AAPAP 51_ FQYTP 56_ DHVVG 61_ PGADI 66_ DPTQI 71_ TFPGC 76_ ICVKT 81_ PCLPG 86_ TCSCL 91_ RHGEN 96_ YDDNS 101_ CLRDI 106_ GSGGK 111_ YAEPV 116_ FECNV 121_ LCRCS 126_ DHCRN 131_ RVVQK 136_ GLQFH 141_ FQVFK 146_ THKKG 151_ WGLRT 156_ LEFIP 161_ KGRFV 166_ CEYAG 171_ EVLGF 176_ SEVQR 181_ RIHLQ 186_ TKSDS 191_ NYIIA 196_ IREHV 201_ YNGQV 206_ METFV 211_ DPTYI 216_ GNIGR 221_ FLNHS 226_ CEPNL 231_ LMIPV 236_ RIDSM 241_ VPKLA 246_ LFAAK 251_ DIVPE 256_ EELSY 261_ DYSGR 266_ YLNLT 271_ VSEDK 276_ ERLDH 281_ GKLRK 286_ PCYCG 291_ AKSCT 296_ AFLPF 301_ DSSLY 306_ CPVEK 311_ SNISC 316_ GNEKE 321_ PSMCG 326_ SAPSV 331_ FPSCK 336_ RLTLE 341_ TMKMM 346_ LDKKQ 351_ IRAIF 356_ LFEFK 361_ MGRKA 366_ AETTR 371_ NINNA 376_ FGPGT 381_ ANERT 386_ VQWWF 391_ KKFCK 396_ GDESL 401_ EDEER 406_ SGRPS 411_ EVDND 416_ QLRAI 421_ IEADP 426_ LTTTR 431_ EVAEE 436_ LNVNH 441_ STVVR 446_ HLKQI 451_ GKVKK 456_ LDKWV 461_ PHELT 466_ ENQKN 471_ RRFEV 476_ SSSLI 481_ LRNHN 486_ EPFLD 491_ RIVTC 496_ DEKWI 501_ LYDNR 506_ RRSAQ 511_ WLDQE 516_ EAPKH 521_ FPKPI 526_ LHPKK 531_ VMVTI 536_ WWSAA 541_ GLIHY 546_ SFLNP 551_ GETIT 556_ SEKYA 561_ QEIDE 566_ MNQKL 571_ QRLQL 576_ ALVNR 581_ KGPIL 586_ LHDNA 591_ RPHVA 596_ QPTLQ 601_ KLNEL 606_ GYEVL 611_ PHPPY 616_ SPDLL 621_ PTNYH 626_ VFKHL 631_ NNFLQ 636_ GKRFH 641_ NQQDA 646_ ENAFQ 651_ EFVES 656_ QSTDF 661_ YATGI 666_ NQLIS 671_ RWQKC 676_VDCNG
1: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Also has kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17403897, PubMed:17877369, PubMed:18263876, PubMed:20521842, PubMed:22231448, PubMed:24573677). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750)